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'''Neurocytoma''' is a rare [[neuropathology tumour]]. | |||
==General== | |||
*Rare. | |||
==Microscopic== | |||
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm]. Accessed on: 12 October 2011.</ref> | |||
*[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | |||
**Similar to Homer-Wright rosette. | |||
*Monomorphic cells with round nuclei and speckled chromatin. | |||
*Perinuclear clearing. | |||
*Ganglion cell differentiation. | |||
*Well-defined cell borders. | |||
*Hyalinized vessels. | |||
*Necrosis absent. | |||
==IHC== | |||
*MIB-1: Usu. low. | |||
*Synapthophysin +ve. | |||
DDx: | |||
*[[Oligodendroglioma]] - do not have the characteristic rosettes. | |||
*[[Ganglioglioma]]. | |||
*[[Ependymoma]]. | |||
*[[Pilocytic astrocytoma]] (with predominantly oligo-like cell component). | |||
* Diffuse leptomeningeal gliomeuronal tumour. | |||
===Images=== | |||
<gallery> | |||
File:Neurocytoma_Histopathology_HE.jpg | Neurocytoma (H&E: WC, Marvin101). | |||
File:Neurocytoma_NeuN.jpg | Nuclear NeuN immunoreactivity (WC, Marvin101): | |||
</gallery> | |||
www: | |||
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm Neurocytoma (ouhsc.edu)]. | |||
*[http://path.upmc.edu/cases/case383.html Neurocytoma - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case561.html Neurocytoma - cerebellar - several images (upmc.edu)]. | |||
==IHC== | |||
*Synaptophysin +ve. | |||
**Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref> | |||
==Molecular== | |||
*FGFR1-TACC1 fusions common.<ref>{{Cite journal | last1 = Sievers | first1 = P. | last2 = Stichel | first2 = D. | last3 = Schrimpf | first3 = D. | last4 = Sahm | first4 = F. | last5 = Koelsche | first5 = C. | last6 = Reuss | first6 = DE. | last7 = Wefers | first7 = AK. | last8 = Reinhardt | first8 = A. | last9 = Huang | first9 = K. | title = FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Jul | year = 2018 | doi = 10.1007/s00401-018-1882-3 | PMID = 29978331 }}</ref> | |||
==See also== | |||
*[[Central neurocytoma]]. | |||
*[[Neuropathology tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Neuropathology tumours]] | |||