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*[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | *[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref> | ||
**Similar to Homer-Wright rosette. | **Similar to Homer-Wright rosette. | ||
*Monomorphic cells with round nuclei and speckled chromatin. | |||
*Perinuclear clearing. | *Perinuclear clearing. | ||
*Ganglion cell differentiation. | |||
*Well-defined cell borders. | *Well-defined cell borders. | ||
*Hyalinized vessels. | |||
*Necrosis absent. | |||
==IHC== | ==IHC== | ||
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*Synaptophysin +ve. | *Synaptophysin +ve. | ||
**Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref> | **Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref> | ||
==Molecular== | |||
*FGFR1-TACC1 fusions common.<ref>{{Cite journal | last1 = Sievers | first1 = P. | last2 = Stichel | first2 = D. | last3 = Schrimpf | first3 = D. | last4 = Sahm | first4 = F. | last5 = Koelsche | first5 = C. | last6 = Reuss | first6 = DE. | last7 = Wefers | first7 = AK. | last8 = Reinhardt | first8 = A. | last9 = Huang | first9 = K. | title = FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | journal = Acta Neuropathol | volume = | issue = | pages = | month = Jul | year = 2018 | doi = 10.1007/s00401-018-1882-3 | PMID = 29978331 }}</ref> | |||
==See also== | ==See also== | ||