Difference between revisions of "Neurocytoma"

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==Microscopic==
==Microscopic==
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm]. Accessed on: 12 October 2011.</ref>
Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm]. Accessed on: 12 October 2011.</ref>
*[[Pineocytoma|Pineocytomatous]]/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
*[[Pineocytoma|Pineocytomatous]]/neurocytic [[rosette]] = irregular rosette with a large meshwork of fibers (neuropil) at the centre.<ref name=pmid16551982>{{cite journal |author=Wippold FJ, Perry A |title=Neuropathology for the neuroradiologist: rosettes and pseudorosettes |journal=AJNR Am J Neuroradiol |volume=27 |issue=3 |pages=488–92 |year=2006 |month=March |pmid=16551982 |doi= |url=}}</ref>
**Similar to Homer-Wright rosette.
**Similar to Homer-Wright rosette.
*Monomorphic cells with round nuclei and speckled chromatin.
*Perinuclear clearing.
*Perinuclear clearing.
*Ganglion cell differentiation.
*Well-defined cell borders.
*Well-defined cell borders.
*Hyalinized vessels.
*Necrosis absent.
==IHC==
*MIB-1: Usu. low.
*Synapthophysin +ve.


DDx:
DDx:
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*[[Ganglioglioma]].
*[[Ganglioglioma]].
*[[Ependymoma]].
*[[Ependymoma]].
*[[Pilocytic astrocytoma]] (with predominantly oligo-like cell component).
* Diffuse leptomeningeal gliomeuronal tumour.
===Images===
<gallery>
File:Neurocytoma_Histopathology_HE.jpg | Neurocytoma (H&E: WC, Marvin101).
File:Neurocytoma_NeuN.jpg | Nuclear NeuN immunoreactivity (WC, Marvin101):
</gallery>


===Images====
www:
www:
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm Neurocytoma (ouhsc.edu)].
*[http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm Neurocytoma (ouhsc.edu)].
*[http://path.upmc.edu/cases/case383.html Neurocytoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case383.html Neurocytoma - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case561.html Neurocytoma - cerebellar - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case561.html Neurocytoma - cerebellar - several images (upmc.edu)].
==IHC==
==IHC==
*Synaptophysin +ve.
*Synaptophysin +ve.
**Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref>
**Most glial tumour -ve.<ref>URL: [http://path.upmc.edu/cases/case383/dx.html http://path.upmc.edu/cases/case383/dx.html]. Accessed on: 15 January 2012.</ref>
==Molecular==
*FGFR1-TACC1 fusions common.<ref>{{Cite journal  | last1 = Sievers | first1 = P. | last2 = Stichel | first2 = D. | last3 = Schrimpf | first3 = D. | last4 = Sahm | first4 = F. | last5 = Koelsche | first5 = C. | last6 = Reuss | first6 = DE. | last7 = Wefers | first7 = AK. | last8 = Reinhardt | first8 = A. | last9 = Huang | first9 = K. | title = FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma. | journal = Acta Neuropathol | volume =  | issue =  | pages =  | month = Jul | year = 2018 | doi = 10.1007/s00401-018-1882-3 | PMID = 29978331 }}</ref>


==See also==
==See also==

Latest revision as of 12:07, 9 July 2018

Neurocytoma is a rare neuropathology tumour.

General

  • Rare.

Microscopic

Features:[1]

  • Pineocytomatous/neurocytic rosette = irregular rosette with a large meshwork of fibers (neuropil) at the centre.[2]
    • Similar to Homer-Wright rosette.
  • Monomorphic cells with round nuclei and speckled chromatin.
  • Perinuclear clearing.
  • Ganglion cell differentiation.
  • Well-defined cell borders.
  • Hyalinized vessels.
  • Necrosis absent.

IHC

  • MIB-1: Usu. low.
  • Synapthophysin +ve.


DDx:


Images

www:

IHC

  • Synaptophysin +ve.
    • Most glial tumour -ve.[3]

Molecular

  • FGFR1-TACC1 fusions common.[4]

See also

References

  1. URL: http://moon.ouhsc.edu/kfung/jty1/Composites/FNA0IE14-Neurocytoma-Micro.htm. Accessed on: 12 October 2011.
  2. Wippold FJ, Perry A (March 2006). "Neuropathology for the neuroradiologist: rosettes and pseudorosettes". AJNR Am J Neuroradiol 27 (3): 488–92. PMID 16551982.
  3. URL: http://path.upmc.edu/cases/case383/dx.html. Accessed on: 15 January 2012.
  4. Sievers, P.; Stichel, D.; Schrimpf, D.; Sahm, F.; Koelsche, C.; Reuss, DE.; Wefers, AK.; Reinhardt, A. et al. (Jul 2018). "FGFR1:TACC1 fusion is a frequent event in molecularly defined extraventricular neurocytoma.". Acta Neuropathol. doi:10.1007/s00401-018-1882-3. PMID 29978331.