Myoepithelial carcinoma

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Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1] It is the malignant counterpart of myoepithelioma.

General

  • Rare.

Microscopic

Features:[2]

  • Myoepithelial cells - may be cytologically very bland.
  • Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
  • Pushing border ("expansile nodular lobulated pattern").
  • No ductal structures.

Note:

  • Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.

DDx:

IHC

  • CAM5.2 +ve.

Molecular

  • Fusions with PLAG1.[3]

See also

References

  1. Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
  2. Xu, B.; Mneimneh, W.; Torrence, DE.; Higgins, K.; Klimstra, D.; Ghossein, R.; Katabi, N. (Feb 2019). "Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.". Am J Surg Pathol. doi:10.1097/PAS.0000000000001218. PMID 30789358.
  3. Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.