Difference between revisions of "Myoepithelial carcinoma"
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==Microscopic== | ==Microscopic== | ||
Features: | Features:<ref name=pmid30789358>{{Cite journal | last1 = Xu | first1 = B. | last2 = Mneimneh | first2 = W. | last3 = Torrence | first3 = DE. | last4 = Higgins | first4 = K. | last5 = Klimstra | first5 = D. | last6 = Ghossein | first6 = R. | last7 = Katabi | first7 = N. | title = Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall. | journal = Am J Surg Pathol | volume = | issue = | pages = | month = Feb | year = 2019 | doi = 10.1097/PAS.0000000000001218 | PMID = 30789358 }}</ref> | ||
*Myoepithelial cells - may be cytologically very bland. | *Myoepithelial cells - may be cytologically very bland. | ||
*Hypocellular centre (hyaline or myxoid) and hypercellular periphery. | *Hypocellular centre (hyaline or myxoid) and hypercellular periphery. | ||
*Pushing border ("expansile nodular lobulated pattern"). | |||
*No ductal structures. | *No ductal structures. | ||
Note: | |||
*Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent. | |||
DDx: | DDx: | ||
Revision as of 01:40, 19 March 2019
Myoepithelial carcinoma, abbreviated MECA a rare malignant salivary gland tumour.[1] It is the malignant counterpart of myoepithelioma.
General
- Rare.
Microscopic
Features:[2]
- Myoepithelial cells - may be cytologically very bland.
- Hypocellular centre (hyaline or myxoid) and hypercellular periphery.
- Pushing border ("expansile nodular lobulated pattern").
- No ductal structures.
Note:
- Overt features of malignancy (necrosis, nuclear atypia, infiltrative growth, proliferation) absent.
DDx:
IHC
- CAM5.2 +ve.
Molecular
- Fusions with PLAG1.[3]
See also
References
- ↑ Kong, M.; Drill, EN.; Morris, L.; West, L.; Klimstra, D.; Gonen, M.; Ghossein, R.; Katabi, N. (Jul 2015). "Prognostic factors in myoepithelial carcinoma of salivary glands: a clinicopathologic study of 48 cases.". Am J Surg Pathol 39 (7): 931-8. doi:10.1097/PAS.0000000000000452. PMID 25970687.
- ↑ Xu, B.; Mneimneh, W.; Torrence, DE.; Higgins, K.; Klimstra, D.; Ghossein, R.; Katabi, N. (Feb 2019). "Misinterpreted Myoepithelial Carcinoma of Salivary Gland: A Challenging and Potentially Significant Pitfall.". Am J Surg Pathol. doi:10.1097/PAS.0000000000001218. PMID 30789358.
- ↑ Dalin, MG.; Katabi, N.; Persson, M.; Lee, KW.; Makarov, V.; Desrichard, A.; Walsh, LA.; West, L. et al. (10 2017). "Multi-dimensional genomic analysis of myoepithelial carcinoma identifies prevalent oncogenic gene fusions.". Nat Commun 8 (1): 1197. doi:10.1038/s41467-017-01178-z. PMID 29084941.