Mucinous breast carcinoma

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Mucinous breast carcinoma
Diagnosis in short

Mucinous breast carcinoma. H&E stain.

LM malignant mucin producing glands - where mucinous component must comprise >90% of the tumour, tumour cells should float in the mucin, glands typically have irregular edges, +/-vessels within the mucin pools
LM DDx other type of breast cancer with a mucinous component (very common), other mucinous tumours
IHC ER +ve, PR +ve, HER2 -ve
Gross pale, glistening, jelly-like appearance
Site breast - see invasive breast cancer

Prevalence uncommon
Prognosis good compared to usu. ductal carcinoma
Clin. DDx other breast tumours

Mucinous breast carcinoma is an uncommon form of breast cancer that has a good prognosis compared to the common invasive ductal carcinoma.

It is also known as mucinous carcinoma of the breast, and colloid carcinoma of the breast.

General

  • Rare.
  • Good prognosis.[1]
  • Usually older women.

Gross

  • Pale, glistening, jelly-like appearance.
  • Well-circumscribed.

Image:

Microscopic

Features:

  • Malignant mucin producing glands.
    • Mucinous component must comprise >90% of the tumour - required for diagnosis.[2]
    • Cells should float in the mucin - key feature.
    • Glands typically have irregular edges.
    • +/-Vessels within the mucin pools.

DDx:

  • DCIS with a mucinous component.
    • Mucin has a homogenous appearance, mucin lacks vascularization, mucin pools have a regular border.

Note:

  • The amount of mucinous component to call mucinous carcinoma varies by anatomical site.
  • All mucinous lesions should be excised.[3]

Images

IHC

  • ER +ve.
  • PR +ve.
  • HER2 -ve.

See also

References

  1. Barkley, CR.; Ligibel, JA.; Wong, JS.; Lipsitz, S.; Smith, BL.; Golshan, M. (Oct 2008). "Mucinous breast carcinoma: a large contemporary series.". Am J Surg 196 (4): 549-51. doi:10.1016/j.amjsurg.2008.06.013. PMID 18809061.
  2. Dogan, E.; Aksoy, S.; Dizdar, O.; Arslan, C.; Dede, DS.; Ozisik, Y.; Altundag, K.. "Pure mucinous carcinoma of the breast: a single center experience.". J BUON 16 (3): 565-7. PMID 22006768.
  3. Jacobs, TW.; Connolly, JL.; Schnitt, SJ. (Sep 2002). "Nonmalignant lesions in breast core needle biopsies: to excise or not to excise?". Am J Surg Pathol 26 (9): 1095-110. PMID 12218567.