Difference between revisions of "Mucinous adenocarcinoma of the ovary"

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#redirect [[Ovarian_tumours#Mucinous_adenocarcinoma_of_the_ovary]]
'''Mucinous adenocarcinoma of the ovary''' is a [[malignant]] [[ovarian tumour]].
 
It is also known as '''ovarian mucinous adenocarcinoma''' and '''ovarian mucinous carcinoma'''.
 
==General==
*Malignant.
*May arise in [[endometriosis]].<ref name=Ref_PBoD1097>{{Ref PBoD |1097}}</ref>
*Poor response to chemotherapy vis-à-vis serous carcinoma.<ref name=pmid19275957>{{Cite journal  | last1 = Shimada | first1 = M. | last2 = Kigawa | first2 = J. | last3 = Ohishi | first3 = Y. | last4 = Yasuda | first4 = M. | last5 = Suzuki | first5 = M. | last6 = Hiura | first6 = M. | last7 = Nishimura | first7 = R. | last8 = Tabata | first8 = T. | last9 = Sugiyama | first9 = T. | title = Clinicopathological characteristics of mucinous adenocarcinoma of the ovary. | journal = Gynecol Oncol | volume = 113 | issue = 3 | pages = 331-4 | month = Jun | year = 2009 | doi = 10.1016/j.ygyno.2009.02.010 | PMID = 19275957 }}</ref>
 
==Gross==
Features:
*Multiloculated.
*Sticky, gelatinous fluid (glycoprotein).
*+/-[[Necrosis]].
*Typically unilateral.<ref name=pmid22885379>{{Cite journal  | last1 = Offman | first1 = SL. | last2 = Longacre | first2 = TA. | title = Clear cell carcinoma of the female genital tract (not everything is as clear as it seems). | journal = Adv Anat Pathol | volume = 19 | issue = 5 | pages = 296-312 | month = Sep | year = 2012 | doi = 10.1097/PAP.0b013e31826663b1 | PMID = 22885379 }}</ref>
 
==Microscopic==
Features:
*Mucinous differentiation.
**Tall [[columnar cell]]s in glands with apical mucin.
***May have an endocervical-like ''or'' intestinal-like appearance - see ''subtypes''.
*Invasive morphology - one of the following:
*#Back-to-back glands/confluent growth pattern.
*#Desmoplastic stromal response.
*#Cribriforming of glands.
*Malignant characteristics:
**+/-Nuclear atypia.
**+/-Necrosis.
**No cilia.
 
DDx:
*[[Mucinous borderline tumour of the ovary]].
*[[Metastatic]] [[mucinous carcinoma]].
 
===Subtypes===
#''Endocervical type''.
#*Less likely to be malignant.
#*More common than malignant type.
#''Intestinal type''.
#*More likely to be malignant.
#*+/-[[Goblet cell]]s.
#**One large clear apical vacuole.
#*If it doesn't look like intestine to you... it probably isn't.
#*May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).
#**Image: [http://www.ispub.com/xml/journals/ijgo/vol9n1/papillary-fig4.jpg]
 
Comparison of mucosa:
*Normal endocervical mucosa: [http://pathology.mc.duke.edu/research/Histo_course/endocx.jpg endocervical mucosa (duke.edu)].
*Normal colonic mucosa: [http://commons.wikimedia.org/wiki/File:Rectal_prolapse_-_intermed_mag.jpg colonic type mucosa (WC)].
 
==IHC==
*CK7 +ve.
*[[CK20]] +ve.
 
==See also==
*[[Ovarian tumours]].
*[[Mucinous adenocarcinoma]].
 
==References==
{{Reflist|2}}


[[Category:Diagnosis]]
[[Category:Diagnosis]]
[[Category:Ovarian tumours]]

Latest revision as of 06:07, 2 May 2015

Mucinous adenocarcinoma of the ovary is a malignant ovarian tumour.

It is also known as ovarian mucinous adenocarcinoma and ovarian mucinous carcinoma.

General

  • Malignant.
  • May arise in endometriosis.[1]
  • Poor response to chemotherapy vis-à-vis serous carcinoma.[2]

Gross

Features:

  • Multiloculated.
  • Sticky, gelatinous fluid (glycoprotein).
  • +/-Necrosis.
  • Typically unilateral.[3]

Microscopic

Features:

  • Mucinous differentiation.
    • Tall columnar cells in glands with apical mucin.
      • May have an endocervical-like or intestinal-like appearance - see subtypes.
  • Invasive morphology - one of the following:
    1. Back-to-back glands/confluent growth pattern.
    2. Desmoplastic stromal response.
    3. Cribriforming of glands.
  • Malignant characteristics:
    • +/-Nuclear atypia.
    • +/-Necrosis.
    • No cilia.

DDx:

Subtypes

  1. Endocervical type.
    • Less likely to be malignant.
    • More common than malignant type.
  2. Intestinal type.
    • More likely to be malignant.
    • +/-Goblet cells.
      • One large clear apical vacuole.
    • If it doesn't look like intestine to you... it probably isn't.
    • May vaguely resemble colorectal adenocarcinoma (hyperchromatic, columnar nuclei, nuclear pleomorphism).

Comparison of mucosa:

IHC

See also

References

  1. ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1097. ISBN 0-7216-0187-1.
  2. ↑ Shimada, M.; Kigawa, J.; Ohishi, Y.; Yasuda, M.; Suzuki, M.; Hiura, M.; Nishimura, R.; Tabata, T. et al. (Jun 2009). "Clinicopathological characteristics of mucinous adenocarcinoma of the ovary.". Gynecol Oncol 113 (3): 331-4. doi:10.1016/j.ygyno.2009.02.010. PMID 19275957.
  3. ↑ Offman, SL.; Longacre, TA. (Sep 2012). "Clear cell carcinoma of the female genital tract (not everything is as clear as it seems).". Adv Anat Pathol 19 (5): 296-312. doi:10.1097/PAP.0b013e31826663b1. PMID 22885379.
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