Difference between revisions of "Mixed germ cell tumour"
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# | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = Mixed_germ_cell_tumour_-_intermed_mag.jpg | |||
| Width = | |||
| Caption = Mixed germ cell tumour. [[H&E stain]]. | |||
| Micro = depends on the components | |||
| Subtypes = | |||
| LMDDx = other [[germ cell tumours]] | |||
| Stains = | |||
| IHC = variable | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[ovary]], [[testis]], [[mediastinum]], other | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = mass | |||
| Symptoms = | |||
| Prevalence = | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
}} | |||
'''Mixed germ cell tumour''' is a [[tumour]] composed on different [[germ cell tumours]]. Most germ cell tumours are mixed. | |||
==General=== | |||
*60% of GCTs are mixed. | |||
Common combinations: | |||
# Teratoma + embryonal carcinoma + endodermal sinus tumour (yolk sac tumour) (TEE). | |||
# Seminoma + embryonal (SE). | |||
# Teratoma + embryonal +(TE). | |||
Memory device: ''TEE'' + all combinations have embryonal carcinoma. | |||
==Microscopic== | |||
Features: | |||
*Depends on components. | |||
Notes: | |||
*If one cannot identify the component... it is probably yolk sac as this has so many different patterns. | |||
===Images=== | |||
<gallery> | |||
Image:Mixed_germ_cell_tumour_-_intermed_mag.jpg | Mixed GCT - intermed mag. (WC/Nephron) | |||
Image:Mixed germ cell tumour - high mag.jpg | Mixed GCT - high mag. (WC/Nephron) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case192/micro.html Mixed germ cell tumour - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case356.html Mixed germ cell tumour - several cases (upmc.edu)]. | |||
===IHC=== | |||
*Beta-hCG +ve - if syncytiotrophoblasts are present. | |||
*AFP +ve - a yolk sac tumour component is present. | |||
*GFAP +ve - if neuroepithelium is present. | |||
==See also== | |||
*[[Germ cell tumours]]. | |||
*[[Testis]]. | |||
*[[Ovarian tumours]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Germ cell tumours]] | |||
[[Category:Genitourinary pathology]] | |||
[[Category:Gynecologic pathology]] | |||
Revision as of 09:50, 20 July 2013
| Mixed germ cell tumour | |
|---|---|
| Diagnosis in short | |
 Mixed germ cell tumour. H&E stain. | |
|
| |
| LM | depends on the components |
| LM DDx | other germ cell tumours |
| IHC | variable |
| Site | ovary, testis, mediastinum, other |
|
| |
| Signs | mass |
Mixed germ cell tumour is a tumour composed on different germ cell tumours. Most germ cell tumours are mixed.
General=
- 60% of GCTs are mixed.
Common combinations:
- Teratoma + embryonal carcinoma + endodermal sinus tumour (yolk sac tumour) (TEE).
- Seminoma + embryonal (SE).
- Teratoma + embryonal +(TE).
Memory device: TEE + all combinations have embryonal carcinoma.
Microscopic
Features:
- Depends on components.
Notes:
- If one cannot identify the component... it is probably yolk sac as this has so many different patterns.
Images
Mixed GCT - intermed mag. (WC/Nephron)
Mixed GCT - high mag. (WC/Nephron)
www:
- Mixed germ cell tumour - several images (upmc.edu).
- Mixed germ cell tumour - several cases (upmc.edu).
IHC
- Beta-hCG +ve - if syncytiotrophoblasts are present.
- AFP +ve - a yolk sac tumour component is present.
- GFAP +ve - if neuroepithelium is present.