Micropapillary urothelial carcinoma

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Micropapillary urothelial carcinoma
Diagnosis in short

Urothelial carcinoma with micropapillary features. H&E stain.
Subtypes (subtype of urothelial carcinoma)
LM DDx conventional urothelial carcinoma, other micropapillary carcinomas (metastases)
IHC CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve
Site urothelium - urinary bladder, ureter, renal pelvis, urethra (males)

Signs hematuria (typical presentation)
Prevalence rare
Prognosis poor (aggressive course)

Micropapillary urothelial carcinoma (abbreviated MPUC), also micropapillary urothelial cell carcinoma (abbreviated MPUCC), is an aggressive variant of urothelial carcinoma.[1]

General

Microscopic

Features:[1]

  • Micropapillae - definitional.
    • Nipple-like structures without fibrovascular cores.
    • Quantity of micropapillary pattern (percentage) is variable.[2]
  • Conventional urothelial carcinoma (typical).

DDx:

  • Metastasis (breast, ovary, lung, pancreas, salivary gland).

Images

Case

www

IHC

Features:

Others:[3]

  • p63 -ve/+ve.
  • p40 -ve/+ve.

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See also

References

  1. 1.0 1.1 1.2 Compérat, E.; Roupret, M.; Yaxley, J.; Reynolds, J.; Varinot, J.; Ouzaïd, I.; Cussenot, O.; Samaratunga, H. (Dec 2010). "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.". Pathology 42 (7): 650-4. doi:10.3109/00313025.2010.522173. PMID 21080874.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chatterjee, D.; Das, A.; Radotra, BD.. "Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study.". Indian J Pathol Microbiol 58 (1): 2-6. doi:10.4103/0377-4929.151153. PMID 25673582.
  3. 3.0 3.1 Lin, X.; Zhu, B.; Villa, C.; Zhong, M.; Kundu, S.; Rohan, SM.; Yang, XJ. (Sep 2014). "The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma.". Hum Pathol 45 (9): 1824-9. doi:10.1016/j.humpath.2014.04.015. PMID 24993315.