Difference between revisions of "Micropapillary urothelial carcinoma"

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{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Urothelial carcinoma with micropapillary features -- intermed mag.jpg
| Width      =
| Caption    = Urothelial carcinoma with micropapillary features. [[H&E stain]].
| Synonyms  =
| Micro      =
| Subtypes  = (subtype of [[urothelial carcinoma]])
| LMDDx      = conventional [[urothelial carcinoma]], other micropapillary carcinomas ([[metastases]])
| Stains    =
| IHC        = CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[urothelium]] - [[urinary bladder]], [[ureter]], renal pelvis, [[urethra]] (males)
| Assdx      =
| Syndromes  =
| Clinicalhx =
| Signs      = [[hematuria]] (typical presentation)
| Symptoms  =
| Prevalence = rare
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = poor (aggressive course)
| Other      =
| ClinDDx    =
| Tx        =
}}
'''Micropapillary urothelial carcinoma''' is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal  | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref>
'''Micropapillary urothelial carcinoma''' is an aggressive variant of [[urothelial carcinoma]].<ref name=pmid21080874>{{Cite journal  | last1 = Compérat | first1 = E. | last2 = Roupret | first2 = M. | last3 = Yaxley | first3 = J. | last4 = Reynolds | first4 = J. | last5 = Varinot | first5 = J. | last6 = Ouzaïd | first6 = I. | last7 = Cussenot | first7 = O. | last8 = Samaratunga | first8 = H. | title = Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases. | journal = Pathology | volume = 42 | issue = 7 | pages = 650-4 | month = Dec | year = 2010 | doi = 10.3109/00313025.2010.522173 | PMID = 21080874 }}</ref>



Revision as of 09:24, 15 June 2015

Micropapillary urothelial carcinoma
Diagnosis in short

Urothelial carcinoma with micropapillary features. H&E stain.
Subtypes (subtype of urothelial carcinoma)
LM DDx conventional urothelial carcinoma, other micropapillary carcinomas (metastases)
IHC CK7 +ve, CK20 +ve/-ve, GATA3 +ve, p63 -ve/+ve
Site urothelium - urinary bladder, ureter, renal pelvis, urethra (males)

Signs hematuria (typical presentation)
Prevalence rare
Prognosis poor (aggressive course)

Micropapillary urothelial carcinoma is an aggressive variant of urothelial carcinoma.[1]

General

Microscopic

Features:[1]

  • Micropapillae.
    • Quantity of micropapillary (percentage) is variable.[2]
  • Conventional urothelial carcinoma (typical).

DDx:

  • Metastasis (breast, ovary, lung, pancreas, salivary gland).

Images

Case

www

IHC

Features:

Others:[3]

  • p63 -ve/+ve.
  • p40 -ve/+ve.

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See also

References

  1. 1.0 1.1 1.2 Compérat, E.; Roupret, M.; Yaxley, J.; Reynolds, J.; Varinot, J.; Ouzaïd, I.; Cussenot, O.; Samaratunga, H. (Dec 2010). "Micropapillary urothelial carcinoma of the urinary bladder: a clinicopathological analysis of 72 cases.". Pathology 42 (7): 650-4. doi:10.3109/00313025.2010.522173. PMID 21080874.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chatterjee, D.; Das, A.; Radotra, BD.. "Invasive micropapillary carcinoma of urinary bladder: a clinicopathological study.". Indian J Pathol Microbiol 58 (1): 2-6. doi:10.4103/0377-4929.151153. PMID 25673582.
  3. 3.0 3.1 Lin, X.; Zhu, B.; Villa, C.; Zhong, M.; Kundu, S.; Rohan, SM.; Yang, XJ. (Sep 2014). "The utility of p63, p40, and GATA-binding protein 3 immunohistochemistry in diagnosing micropapillary urothelial carcinoma.". Hum Pathol 45 (9): 1824-9. doi:10.1016/j.humpath.2014.04.015. PMID 24993315.