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Difference between revisions of "Medulloblastoma"
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→Subtypes: prognosis
Jensflorian (talk | contribs) (IHC + DDx) |
Jensflorian (talk | contribs) (→Subtypes: prognosis) |
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*Classic medulloblastoma (~85% of all medulloblastomas). | *Classic medulloblastoma (~85% of all medulloblastomas). | ||
*Variants of medulloblastoma (~15% of all medulloblastomas together): | *Variants of medulloblastoma (~15% of all medulloblastomas together): | ||
*#Anaplastic | *#Anaplastic / Large cell variant. | ||
*#Desmoplastic/nodular medulloblastoma (DNMB). | *#Desmoplastic/nodular medulloblastoma (DNMB). | ||
*#Medulloblastoma with extensive nodularity (MBEN). | *#Medulloblastoma with extensive nodularity (MBEN). | ||
====Anaplastic variant==== | ====Anaplastic variant==== | ||
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*Severe anaplasia. | *Severe anaplasia. | ||
*Polygonal cells. | *Polygonal cells. | ||
==Prognosis== | |||
*Prognosis based on histology:<ref name=pmid18841049>{{cite journal |author=Gulino A, Arcella A, Giangaspero F |title=Pathological and molecular heterogeneity of medulloblastoma |journal=Curr Opin Oncol |volume=20 |issue=6 |pages=668–75 |year=2008 |month=November |pmid=18841049 |doi=10.1097/CCO.0b013e32831369f4 |url=}}</ref><ref name=pmid20940197>{{cite journal |author=Rutkowski S, von Hoff K, Emser A, ''et al.'' |title=Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis |journal=J Clin Oncol |volume=28 |issue=33 |pages=4961–4968 |year=2010 |month=November |pmid=20940197 |doi=10.1200/JCO.2010.30.2299 |url=}}</ref><ref>{{Cite journal | last1 = Rutkowski | first1 = S. | last2 = Bode | first2 = U. | last3 = Deinlein | first3 = F. | last4 = Ottensmeier | first4 = H. | last5 = Warmuth-Metz | first5 = M. | last6 = Soerensen | first6 = N. | last7 = Graf | first7 = N. | last8 = Emser | first8 = A. | last9 = Pietsch | first9 = T. | title = Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. | journal = N Engl J Med | volume = 352 | issue = 10 | pages = 978-86 | month = Mar | year = 2005 | doi = 10.1056/NEJMoa042176 | PMID = 15758008 }} | |||
</ref> DNMB & MBEN > classic > anaplastic variant, large cell variant. | |||
==See also== | ==See also== | ||