Difference between revisions of "Medical liver disease"

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→‎Steatohepatitis: tweak, re-work
(→‎Steatohepatitis: tweak, re-work)
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#Alcohol = alcoholic steatohepatitis (ASH).
#Alcohol = alcoholic steatohepatitis (ASH).
#Not alcohol = non-alcoholic steatohepatitis (NASH).
#Not alcohol = non-alcoholic steatohepatitis (NASH).
#Other.


Notes:
Notes:
*Pathologists can comment on the etiology; however, the histomorphology is not distinctive. In other words, ''ASH'' and ''NASH'' are clinical diagnoses.
*Pathologists can comment on the etiology; however, the histomorphology is not distinctive. In other words, ''ASH'' and ''NASH'' are clinical diagnoses.
*''Steatohepatitis'' is a misnomer.  It is '''not''' an ''-itis''; inflammation is '''not''' the (predominant) pathologic process.


===Microscopic===
===Microscopic===
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**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal  | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi =  | PMID = 14991537 }}</ref>
**Late-stage disease - portal bridging.<ref name=pmid14991537>{{Cite journal  | last1 = Gramlich | first1 = T. | last2 = Kleiner | first2 = DE. | last3 = McCullough | first3 = AJ. | last4 = Matteoni | first4 = CA. | last5 = Boparai | first5 = N. | last6 = Younossi | first6 = ZM. | title = Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. | journal = Hum Pathol | volume = 35 | issue = 2 | pages = 196-9 | month = Feb | year = 2004 | doi =  | PMID = 14991537 }}</ref>


Important note:
Image: [http://commons.wikimedia.org/wiki/File:Steatohepatitis_high_mag.jpg Steatohepatitis (WC)].
*''Steatohepatitis'' is a misnomer. It is '''not''' an ''-itis'', i.e. inflammation is '''not''' the (predominant) pathologic process.


Image: [http://commons.wikimedia.org/wiki/File:Steatohepatitis_high_mag.jpg Steatohepatitis (WC)].
DDx:
*[[Wilson disease]].
*[[Hepatitis C]].
*[[Drug reaction]].


===Grading steatohepatitis===
===Grading steatohepatitis===
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