Difference between revisions of "Lymph node pathology"

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Lymph node pathology (view source)

Revision as of 03:40, 10 December 2013

1,406 bytes removed ,  03:40, 10 December 2013
→‎Dermatopathic lymphadenopathy: split-out
(→‎Kikuchi disease: split-out)
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==Dermatopathic lymphadenopathy==
==Dermatopathic lymphadenopathy==
===General===
{{Main|Dermatopathic lymphadenopathy}}
*Lymphadenopathy associated with a skin lesion - '''key feature'''.
*May be benign ''or'' malignant (e.g. T-cell lymphoma).
 
===Microscopic===
Features:<ref name=ILNP226>{{Ref ILNP|226}}</ref>
*Abundant histiocytes & special histiocytes - in loose irregular clusters - located in the sinuses, i.e. sinus histiocytosis - '''key feature''':
**Do ''not'' form granuloma; may be similar to ''toxoplasma''.
*Plasma cells (medulla).
*Eosinophils.
 
Histiocytes & special histiocytes:
*Histiocytes:
**+/-Melanin pigment '''key feature''' (if present).
**Lipid-laden macrophages.
*Interdigitating dendritic cells:
**Need IHC to identify definitively.
*Langerhans cells:
**Classically have a kidney bean nuclei.
**Need IHC to identify definitively.
 
DDx:
*[[Metastatic]] [[malignant melanoma]] - (melanin) pigmented cells have nuclear atypia, not histiocytes.
*[[Sinus histiocytosis]] - no cells with melanin.
 
====Images====
<gallery>
Image:Dermatopathic_lymphadenopathy_-_very_low_mag.jpg | DL - very low mag. (WC)
Image:Dermatopathic_lymphadenopathy_-_low_mag.jpg | DL - low mag. (WC)
Image:Dermatopathic_lymphadenopathy_-_intermed_mag.jpg | DL - intermed. mag. (WC)
Image:Dermatopathic_lymphadenopathy_-_high_mag.jpg | DL - high mag. (WC)
Image:Dermatopathic_lymphadenopathy_-_very_high_mag.jpg | DL - very high mag. (WC)
</gallery>
 
===IHC===
*Interdigitating dendritic cells: S100 +ve, CD1a -ve.
*Langerhans cells: S100 +ve, CD1a +ve.


==Kimura lymphadenopathy==
==Kimura lymphadenopathy==
Michael
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