Lung metastasis

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Lung metastasis, also pulmonary metastasis and metastatic lung disease, is relatively common and generally carries a poor prognosis.

General

  • Relatively common.

Microscopic

Features:

  • Variable - dependent on site of origin.

Colorectal adenocarcinoma:

  • Typically gland forming.
    • Ellipsoid/elongated pseudostratified nuclei with moderate nuclear atypia.
    • +/-Dirty necrosis.

IHC

  • TTF-1 -ve (may be positive).
  • CK20 +ve/-ve (+ve in colorectal carcinoma, -ve in lung primaries).
  • GATA3 +ve/-ve (usu. +ve in urothelial carcinoma, -ve in lung primaries[1]).

See also

References

  1. ↑ Chang, A.; Amin, A.; Gabrielson, E.; Illei, P.; Roden, RB.; Sharma, R.; Epstein, JI. (Oct 2012). "Utility of GATA3 immunohistochemistry in differentiating urothelial carcinoma from prostate adenocarcinoma and squamous cell carcinomas of the uterine cervix, anus, and lung.". Am J Surg Pathol 36 (10): 1472-6. doi:10.1097/PAS.0b013e318260cde7. PMID 22982890.
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