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Difference between revisions of "Liver neoplasms"
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→Hepatocellular carcinoma: moer
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**CD34+ staining cells, suggesting loss of epithelial cells that form the sinusoids. | **CD34+ staining cells, suggesting loss of epithelial cells that form the sinusoids. | ||
**Loss of structures seen in a normal liver lobule (bile ductules, portal triad). | **Loss of structures seen in a normal liver lobule (bile ductules, portal triad). | ||
**Invasion of the portal tract - useful in well-diff. lesions.<ref name=pmid19177576>{{Cite journal | last1 = Kojiro | first1 = M. | last2 = Wanless | first2 = IR. | last3 = Alves | first3 = V. | last4 = Badve | first4 = S. | last5 = Balabaud | first5 = C. | last6 = Bedossa | first6 = P. | last7 = Bhathal | first7 = P. | last8 = Bioulac-Sage | first8 = P. | last9 = Brunt | first9 = EM. | title = Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. | journal = Hepatology | volume = 49 | issue = 2 | pages = 658-64 | month = Feb | year = 2009 | doi = 10.1002/hep.22709 | PMID = 19177576 | url = http://onlinelibrary.wiley.com/doi/10.1002/hep.22709/pdf }}</ref> | |||
Additional findings:<ref>Adapted from STC (19 Jan 2009).</ref> | Additional findings:<ref>Adapted from STC (19 Jan 2009).</ref> | ||
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Edmondson-Steiner grading system:<ref name=pmid13160935>Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. EDMONDSON HA, STEINER PE. Cancer. 1954 May;7(3):462-503. PMID 13160935.</ref><ref name=macsween5th>{{Ref MacSween|783}}</ref> | Edmondson-Steiner grading system:<ref name=pmid13160935>Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. EDMONDSON HA, STEINER PE. Cancer. 1954 May;7(3):462-503. PMID 13160935.</ref><ref name=macsween5th>{{Ref MacSween|783}}</ref> | ||
*Well-differentiated. | *Well-differentiated. | ||
** | **Some say "it cannot be diagnosed on biopsy,"<ref>AP. 28 May 2009.</ref> as it cannot be reliably differentiated from a regenerative nodule. | ||
*Moderately differentiated. | *Moderately differentiated. | ||
**Round, regular nuclei, some hyperchromatism, nucleoli present, increase NC ratio. | **Round, regular nuclei, some hyperchromatism, nucleoli present, increase NC ratio. | ||