Difference between revisions of "Leydig cell tumour"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Leydig_cell_tumour2.jpg | |||
| Width = | |||
| Caption = Leydig cell tumour. [[H&E stain]]. | |||
| Micro = cytoplasmic vacuolization, cytoplasm - clear to eosinophilic, +/-''Reinke crystals'' (cylindrical crystalloid - eosinophilic cytoplasmic bodies), +/-[[nucleoli]] common, round nuclei | |||
| Subtypes = | |||
| LMDDx = [[spermatocytic seminoma]] (testis only), [[pregnancy luteoma]] (females only), [[Sertoli-Leydig cell tumour]] | |||
| Stains = | |||
| IHC = inhibin-alpha +ve, calretinin +ve, melan A +ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = solid, red/tan | |||
| Grossing = | |||
| Site = [[testis]] | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = +/-elevated testosterone | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other testicular tumours | |||
}} | |||
'''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]]. | '''Leydig cell tumour''', also known as '''interstitial cell tumour''', is an uncommon benign sex cord-stromal tumour, typically seen in the [[testis]]. | ||
''Interstitial cell tumour'' should '''not''' be confused with ''[[Renomedullary interstitial cell tumour]]''. | |||
==General== | ==General== | ||
| Line 35: | Line 67: | ||
==IHC== | ==IHC== | ||
*Inhibin-alpha. | *Inhibin-alpha +ve. | ||
*Calretinin.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref> | *Calretinin +ve.<ref>URL: [http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm]. Accessed on: 18 May 2010.</ref><ref name=pmid15950053>{{cite journal |author=Bar-Shira Maymon B, Yavetz H, Yogev L, ''et al.'' |title=Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia |journal=Acta Histochem. |volume=107 |issue=2 |pages=105–12 |year=2005 |pmid=15950053 |doi=10.1016/j.acthis.2005.02.002 |url=}}</ref> | ||
*Melan A.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref> | *Melan A +ve.<ref name=pmid12966351>{{cite journal |author=Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN |title=Melan-A (A103) and inhibin expression in ovarian neoplasms |journal=Appl. Immunohistochem. Mol. Morphol. |volume=11 |issue=3 |pages=244–9 |year=2003 |month=September |pmid=12966351 |doi= |url=}}</ref> | ||
**AKA ''MART-1''. | **[[AKA]] ''MART-1''. | ||
**Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | **Expressed in [[melanoma]], [[adrenal gland|adrenal tissue]], steroid-secreting tumours. | ||
Revision as of 04:12, 18 November 2013
| Leydig cell tumour | |
|---|---|
| Diagnosis in short | |
 Leydig cell tumour. H&E stain. | |
|
| |
| LM | cytoplasmic vacuolization, cytoplasm - clear to eosinophilic, +/-Reinke crystals (cylindrical crystalloid - eosinophilic cytoplasmic bodies), +/-nucleoli common, round nuclei |
| LM DDx | spermatocytic seminoma (testis only), pregnancy luteoma (females only), Sertoli-Leydig cell tumour |
| IHC | inhibin-alpha +ve, calretinin +ve, melan A +ve |
| Gross | solid, red/tan |
| Site | testis |
|
| |
| Prevalence | uncommon |
| Blood work | +/-elevated testosterone |
| Prognosis | benign |
| Clin. DDx | other testicular tumours |
Leydig cell tumour, also known as interstitial cell tumour, is an uncommon benign sex cord-stromal tumour, typically seen in the testis.
Interstitial cell tumour should not be confused with Renomedullary interstitial cell tumour.
General
- Arises from the interstitial cell.
- May be associated with increased testosterone.
Gross
- Solid, lobulated.
- Red/tan.
Image:
Microscopic
Features:[1]
- Vacuolization (cytoplasm) - key feature.
- Cytoplasm - clear to eosinophilic - important.
- Reinke crystals - classic finding, usually not present.
- Cylindrical crystalloid eosinophilic cytoplasmic bodies.
- Nucleoli common.
- Round nuclei.
DDx:
- Spermatocytic seminoma - may have eosinophilic cytoplasm.
- Pregnancy luteoma - occurs during pregnancy, as the name implies.
Images
Leydig cell tumour - low mag. (WC)
Leydig cell tumour - intermed. mag. (WC)
Leydig cell tumour - high mag. (WC)
www:
IHC
- Inhibin-alpha +ve.
- Calretinin +ve.[2][3]
- Melan A +ve.[4]
- AKA MART-1.
- Expressed in melanoma, adrenal tissue, steroid-secreting tumours.
See also
References
- ↑ Zhou, Ming; Magi-Galluzzi, Cristina (2006). Genitourinary Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 581. ISBN 978-0443066771.
- ↑ URL: http://www.antibodybeyond.com/reviews/cell-markers/leydig-cell-marker.htm. Accessed on: 18 May 2010.
- ↑ Bar-Shira Maymon B, Yavetz H, Yogev L, et al. (2005). "Detection of calretinin expression in abnormal immature Sertoli cells in non-obstructive azoospermia". Acta Histochem. 107 (2): 105–12. doi:10.1016/j.acthis.2005.02.002. PMID 15950053.
- ↑ Yao DX, Soslow RA, Hedvat CV, Leitao M, Baergen RN (September 2003). "Melan-A (A103) and inhibin expression in ovarian neoplasms". Appl. Immunohistochem. Mol. Morphol. 11 (3): 244–9. PMID 12966351.