Difference between revisions of "Langerhans cell histiocytosis"

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DDx:
DDx:
*[[Kimura disease]].
*[[Kimura disease]] - eosinophilia.
*See ''[[Lymph node pathology]]''.
*See ''[[lymph node pathology]]''.


===IHC===
===IHC===

Revision as of 04:05, 16 March 2011

Langerhans cell histiocytosis, abbreviated LCH, is a rare genetic disorder of tissue macrophages. It broadly fits into the category of histiocytoses.

General

Microscopic

Features:

  • Langerhans cells histiocytes - key feature.
    • Clusters of cells (histiocytes) with a reniform (kidney-shaped) nucleus and abundant foamy cytoplasm.
      • Nucleus may look like a "coffee bean", i.e. have nuclear grooves (similar to those in papillary thyroid carcinoma) -- appearance dependent on the rotation of the nucleus.[1]
      • Chromatin pattern: fine granular, light gray.
  • +/-Eosinophils - often prominent.

Images:

DDx:

IHC

  • CD1a +ve.
  • S100 +ve.

See also

References

  1. BN. 15 March 2011.