Difference between revisions of "Intratumoural lymphocytic response in colorectal carcinoma"

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Features:
Features:
*>10 lymphocytes/0.94 mm<sup>2</sup>.<ref name=pmid12717242>{{Cite journal  | last1 = Greenson | first1 = JK. | last2 = Bonner | first2 = JD. | last3 = Ben-Yzhak | first3 = O. | last4 = Cohen | first4 = HI. | last5 = Miselevich | first5 = I. | last6 = Resnick | first6 = MB. | last7 = Trougouboff | first7 = P. | last8 = Tomsho | first8 = LD. | last9 = Kim | first9 = E. | title = Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability. | journal = Am J Surg Pathol | volume = 27 | issue = 5 | pages = 563-70 | month = May | year = 2003 | doi =  | PMID = 12717242 }}</ref> †
*>10 lymphocytes/0.94 mm<sup>2</sup>.<ref name=pmid12717242>{{Cite journal  | last1 = Greenson | first1 = JK. | last2 = Bonner | first2 = JD. | last3 = Ben-Yzhak | first3 = O. | last4 = Cohen | first4 = HI. | last5 = Miselevich | first5 = I. | last6 = Resnick | first6 = MB. | last7 = Trougouboff | first7 = P. | last8 = Tomsho | first8 = LD. | last9 = Kim | first9 = E. | title = Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability. | journal = Am J Surg Pathol | volume = 27 | issue = 5 | pages = 563-70 | month = May | year = 2003 | doi =  | PMID = 12717242 }}</ref> †
**Lymphocytes should be between the tumour cells.<ref name=pmid12717242/><ref name=pmid19638537/> ††
**Lymphocytes must be between the tumour cells.<ref name=pmid12717242/><ref name=pmid19638537/> ††
***Other lymphocytes do not count.
***Lymphocytes elsewhere, e.g. in the peritumoural stroma, do ''not'' count.


Note:
Note:
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*[http://jcp.bmjjournals.com/content/62/8/679/F3.large.jpg TILs in endometrial carcinoma (bmjjournals.com)].<ref name=pmid19638537>{{Cite journal  | last1 = Garg | first1 = K. | last2 = Soslow | first2 = RA. | title = Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma. | journal = J Clin Pathol | volume = 62 | issue = 8 | pages = 679-84 | month = Aug | year = 2009 | doi = 10.1136/jcp.2009.064949 | PMID = 19638537 | URL = http://jcp.bmjjournals.com/content/62/8/679.full?related-urls=yes&legid=jclinpath;62/8/679 }}</ref>
*[http://jcp.bmjjournals.com/content/62/8/679/F3.large.jpg TILs in endometrial carcinoma (bmjjournals.com)].<ref name=pmid19638537>{{Cite journal  | last1 = Garg | first1 = K. | last2 = Soslow | first2 = RA. | title = Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma. | journal = J Clin Pathol | volume = 62 | issue = 8 | pages = 679-84 | month = Aug | year = 2009 | doi = 10.1136/jcp.2009.064949 | PMID = 19638537 | URL = http://jcp.bmjjournals.com/content/62/8/679.full?related-urls=yes&legid=jclinpath;62/8/679 }}</ref>
*[http://ajcp.ascpjournals.org/content/134/3/478/F2.expansion.html TILs in CRC (ascpjournals.org)].<ref name=pmid20716806>{{Cite journal  | last1 = Ross | first1 = JS. | last2 = Torres-Mora | first2 = J. | last3 = Wagle | first3 = N. | last4 = Jennings | first4 = TA. | last5 = Jones | first5 = DM. | title = Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 478-90 | month = Sep | year = 2010 | doi = 10.1309/AJCP2Y8KTDPOAORH | PMID = 20716806 }}</ref>
*[http://ajcp.ascpjournals.org/content/134/3/478/F2.expansion.html TILs in CRC (ascpjournals.org)].<ref name=pmid20716806>{{Cite journal  | last1 = Ross | first1 = JS. | last2 = Torres-Mora | first2 = J. | last3 = Wagle | first3 = N. | last4 = Jennings | first4 = TA. | last5 = Jones | first5 = DM. | title = Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. | journal = Am J Clin Pathol | volume = 134 | issue = 3 | pages = 478-90 | month = Sep | year = 2010 | doi = 10.1309/AJCP2Y8KTDPOAORH | PMID = 20716806 }}</ref>
==See also==
==See also==
*[[Colorectal adenocarcinoma]].
*[[Colorectal adenocarcinoma]].

Revision as of 17:03, 16 December 2015

Intratumoural lymphocytic response in colorectal carcinoma in a case with microsatellite instability. H&E stain. (WC)

This article deals with intratumoural lymphocytic response in colorectal carcinoma. It is usually just referred as intratumoural lymphocytic response.

It is also known as tumour-infiltrating lymphocytes, abbreviated TILs.

General

  • Finding is suggestive of microsatellite instabillity.[1]

Microscopic

Features:

  • >10 lymphocytes/0.94 mm2.[2] †
    • Lymphocytes must be between the tumour cells.[2][3] ††
      • Lymphocytes elsewhere, e.g. in the peritumoural stroma, do not count.

Note:

  • † Greenson et al. says >2 lymphocytes/HPF, where 5 HPF are sampled. Since the sample area given by Greenson et al. is 0.94 mm2, their field diameter is ~ 0.4892 mm. This field diameter corresponds to a 20 mm eye piece (0.4892 mm * 40x = 19.57 mm).
    • Many microscopes in use today have a field diameter at 40x of ~ 0.55 mm; thus, 4 fields would be approximately 0.95 mm2.
  • †† Definitions vary substantially - some authors consider lymphocytes adjacent to the tumour (in the stroma around the tumour cells) "intratumoural".[4]

Images

  • TILs - high mag. (WC)

  • TILS - very high mag. (WC)

  • TILs - high mag.

  • TILs - very high mag.

  • TILs - extremely high mag.

www:

See also

References

  1. ↑ Iacopetta, B.; Grieu, F.; Amanuel, B. (Dec 2010). "Microsatellite instability in colorectal cancer.". Asia Pac J Clin Oncol 6 (4): 260-9. doi:10.1111/j.1743-7563.2010.01335.x. PMID 21114775.
  2. ↑ 2.0 2.1 Greenson, JK.; Bonner, JD.; Ben-Yzhak, O.; Cohen, HI.; Miselevich, I.; Resnick, MB.; Trougouboff, P.; Tomsho, LD. et al. (May 2003). "Phenotype of microsatellite unstable colorectal carcinomas: Well-differentiated and focally mucinous tumors and the absence of dirty necrosis correlate with microsatellite instability.". Am J Surg Pathol 27 (5): 563-70. PMID 12717242.
  3. ↑ 3.0 3.1 Garg, K.; Soslow, RA. (Aug 2009). "Lynch syndrome (hereditary non-polyposis colorectal cancer) and endometrial carcinoma.". J Clin Pathol 62 (8): 679-84. doi:10.1136/jcp.2009.064949. PMID 19638537.
  4. ↑ Ropponen, KM.; Eskelinen, MJ.; Lipponen, PK.; Alhava, E.; Kosma, VM. (Jul 1997). "Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer.". J Pathol 182 (3): 318-24. doi:10.1002/(SICI)1096-9896(199707)182:3318::AID-PATH8623.0.CO;2-6. PMID 9349235.
  5. ↑ Ross, JS.; Torres-Mora, J.; Wagle, N.; Jennings, TA.; Jones, DM. (Sep 2010). "Biomarker-based prediction of response to therapy for colorectal cancer: current perspective.". Am J Clin Pathol 134 (3): 478-90. doi:10.1309/AJCP2Y8KTDPOAORH. PMID 20716806.
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