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Inflammatory pseudopolyp (view source)
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Inflammatory polyp -- low mag.jpg | |||
| Width = | |||
| Caption = Inflammatory polyp. [[H&E stain]]. | |||
| Micro = polypoid shape, inflammatory cells - esp. [[neutrophils]] | |||
| Subtypes = | |||
| LMDDx = [[juvenile polyp]], [[mucosal prolapse]], [[adenomatous polyps]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[colon]], [[rectum]], others | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = +/-[[inflammatory bowel disease]] | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = not common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = other types of polyps | |||
}} | |||
{{ Infobox external links | |||
| Name = {{PAGENAME}} | |||
| EHVSC = 9992 | |||
| pathprotocols = | |||
| wikipedia = | |||
| pathoutlines = | |||
}} | |||
'''Inflammatory pseudopolyp''' is a benign polypoid lesion usually seen in the context of [[inflammatory bowel disease]]. | |||
It is also referred to as '''inflammatory polyp'''. | |||
==General== | |||
*Not a true polyp. | |||
*The label ''inflammatory pseudopolyp'' = [[inflammatory bowel disease]] (IBD). | |||
**If there is no history of IBD... reconsider the diagnosis. | |||
==Microscopic== | |||
Features: | |||
*Polypoid shape. | |||
*Inflammation - esp. neutrophils - '''key feature'''. | |||
Negatives: | |||
*No nuclear atypia. | |||
**May have focal nuclear hyperchromasia and nuclear enlargement. | |||
*No dilated glands. | |||
DDx: | |||
*[[Juvenile polyp]]. | |||
*[[Mucosal prolapse]].<ref name=pmid21607734>{{Cite journal | last1 = Aust | first1 = DE. | last2 = Rüschoff | first2 = J. | title = [Polyps of the colorectum: non-neoplastic and non-hamartomatous]. | journal = Pathologe | volume = 32 | issue = 4 | pages = 297-302 | month = Jul | year = 2011 | doi = 10.1007/s00292-011-1435-1 | PMID = 21607734 }}</ref> | |||
**[[Solitary rectal ulcer]]. | |||
===Images=== | |||
<gallery> | |||
Image: Inflammatory polyp -- very low mag.jpg | IP - very low mag. | |||
Image: Inflammatory polyp -- low mag.jpg | IP - low mag. | |||
Image: Inflammatory polyp -- intermed mag.jpg | IP - intermed. mag. | |||
Image: Inflammatory polyp -- high mag.jpg | IP - high mag. | |||
</gallery> | |||
www: | |||
*[http://www.humpath.com/spip.php?article8234&id_document=18554 Pseudopolyp (humpath.com)]. | |||
*[http://missinglink.ucsf.edu/lm/IDS_106_LowerGI/Lower_GI_histo_small/24-UC-pseudoplp.jpg Pseudopolyp (ucsf.edu)]. | |||
==Sign out== | |||
<pre> | |||
SIGMOID COLON POLYP, PERI-DIVERTICULAR, BIOPSY: | |||
- INFLAMMATORY PSEUDOPOLYP. | |||
</pre> | |||
<pre> | |||
POLYP, DESCENDING COLON, BIOPSY: | |||
- INFLAMED POLYPOID FRAGMENT OF COLORECTAL-TYPE MUCOSA. | |||
-- NEGATIVE FOR DYSPLASIA. | |||
</pre> | |||
===Diverticular disease-associated=== | |||
<pre> | |||
Polyp, Sigmoid Colon, Polypectomy: | |||
- Colonic mucosa with ulceration, acute inflammation and granulation tissue. | |||
- NEGATIVE for dysplasia. | |||
Comment: | |||
This may represent a polyp seen in the context of diverticular disease. Other | |||
considerations include ischemia, idiopathic inflammation and infections. | |||
Clinical correlation is suggested. | |||
</pre> | |||
====Block letters==== | |||
<pre> | |||
POLYP (AT EDGE OF DIVERTICULUM), SIGMOID COLON, POLYPECTOMY: | |||
- GRANULATION TISSUE AND SCANT BENIGN EPITHELIUM. | |||
- NO EVIDENCE OF DYSPLASIA. | |||
</pre> | |||
===Micro=== | |||
The sections show a fragment of colorectal mucosa with focal ulceration, acute inflammation and a well-vascularized stroma with plump stromal cells. Occasional stromal cells have nuclear hyperchromasia. | |||
====Alternate==== | |||
The sections show a fragment of tissue with scant benign epithelium, acute and chronic | |||
inflammation (neutrophils and plasma cells predominantly), abundant blood vessels with | |||
reactive endothelial cells and plump stromal cells. Occasional stromal cells have nuclear hyperchromasia but do not show significant atypia. | |||
==See also== | |||
*[[Gastrointestinal tract polyps]]. | |||
*[[Mucosal prolapse syndrome]]. | |||
*[[Colon]]. | |||
*[[Nasal polyps]]. | |||
==References== | |||
{{Reflist|1}} | |||
[[Category:Diagnosis]] | |||