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Difference between revisions of "High-grade papillary urothelial carcinoma"
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High-grade papillary urothelial carcinoma (view source)
Revision as of 02:52, 14 November 2013
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Micro = papillae with "architectural complexity" (fused papillae, branching of papillae), +/-nuclear pleomorphism, nuclear enlargement - often 4-5x the size of stromal lymphocytes, mitoses (common), +/-invasion into the lamina propria (common) | |||
| Subtypes = | |||
| LMDDx = [[low-grade papillary urothelial carcinoma]], [[urothelial carcinoma in situ]], [[squamous cell carcinoma]] | |||
| Stains = | |||
| IHC = Ki-67 high (>35% of cells) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = exophytic mass, frond-like appearance, friable | |||
| Grossing = | |||
| Site = [[urothelium]] - usu. [[urinary bladder]] | |||
| Assdx = | |||
| Syndromes = [[Lynch syndrome]] | |||
| Clinicalhx = | |||
| Signs = hematuria | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = dependent on stage, usu. moderate | |||
| Other = | |||
| ClinDDx = [[low-grade papillary urothelial carcinoma]] | |||
}} | |||
'''High-grade papillary urothelial carcinoma''', abbreviated '''HGPUC''', is a common form of [[cancer]] that arises from the [[urothelium]]. | '''High-grade papillary urothelial carcinoma''', abbreviated '''HGPUC''', is a common form of [[cancer]] that arises from the [[urothelium]]. | ||
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*"High grade nuclear features": | *"High grade nuclear features": | ||
**Nuclear pleomorphism - often 4-5x the size of stromal lymphocytes.<ref name=Ref_GUP161>{{Ref GUP|161}}</ref> | **Nuclear pleomorphism - often 4-5x the size of stromal lymphocytes.<ref name=Ref_GUP161>{{Ref GUP|161}}</ref> | ||
* | *Papillae with "architectural complexity": | ||
**Fused | **Fused papillae - common. | ||
** | **Branching of papillae common. | ||
*Mitoses common. | *Mitoses - common. | ||
*+/-Invasion into the lamina propria. | *+/-Invasion into the lamina propria - relatively common. | ||
Note: | Note: | ||