Hepatitis B

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Hepatitis B is a relatively common medical liver disease caused by the hepatitis B virus.

General

Associated pathology:

Microscopic

Features:

  • Lobular inflammation - this is non-specific finding.
    • Hepatocyte necrosis:
      • Necrotic hepatocytes look a lot like neutrophils - however:
        • Cytoplasm is more pink.
        • Round apoptotic bodies.
  • Ground glass hepatocytes - important.

DDx:

Image

Portal triads, expanded, inflamed and without sharp edges. Inflammation amid hepatocytes. (40X).Reticulin with bridging necrosis (100X).
Reticulin with extensive piecemeal necrosis (100X).PAS without diastase with extensive piecemeal necrosis (100X).
Trichrome with bridging, no nodules or extensive bridging on slides as a whole (100X).Ground glass hepatocytes (400X).

Hepatitis B. Metavir activity index 3. Piecemeal necrosis 2. Lobular necrosis 2. Fibrosis stage 3. Portal triads, expanded, inflamed and without sharp edges. Inflammation amid hepatocytes. (TL 40X). Reticulin with bridging necrosis (TR 100X). Reticulin with extensive piecemeal necrosis (ML 100X). PAS without diastase with extensive piecemeal necrosis (MR 100X). Trichrome with bridging, no nodules or extensive bridging on slides as a whole (BL 100X). Ground glass hepatocytes (BR 400X).

IHC

  • Hepatitis B +ve.

See also

References

  1. Leuridan, E.; Van Damme, P. (Jul 2011). "Hepatitis B and the need for a booster dose.". Clin Infect Dis 53 (1): 68-75. doi:10.1093/cid/cir270. PMID 21653306.