Difference between revisions of "Haematopoiesis"

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'''Haematopoiesis''' making blood.
'''Haematopoiesis''' is the making of blood. Problems in haematopoiesis are numberous and the domain of hematology and [[hematopathology]].


==Normal haematopoiesis==
===Microscopic===
One should see three cell lines:<ref>URL: [http://emedicine.medscape.com/article/199003-overview http://emedicine.medscape.com/article/199003-overview]. Accessed on: 22 November 2010.</ref>
One should see three cell lines:<ref>URL: [http://emedicine.medscape.com/article/199003-overview http://emedicine.medscape.com/article/199003-overview]. Accessed on: 22 November 2010.</ref>
*Erythroid (red blood cells).  
*Erythroid cells.  
*Myeloid (white blood cells).  
*Myeloid cells.  
*Megakaryocytic (platelets).
*Megakaryocytes.


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Extramedullary_haematopoiesis_-_endometrial_polyp_-_high_mag.jpg Extramedullary haematopoiesis - sort-of - high mag. (WC)] - shows nucleated [[RBC]]s.
<gallery>
Image:Extramedullary_haematopoiesis_-_endometrial_polyp_-_high_mag.jpg | Nucleated RBCs - high mag. (WC)
</gallery>
www:
*[http://www.ouhsc.edu/histology/Glass%20slides/75_16.jpg Megakaryocyte (ouhsc.edu)].<ref>URL: [http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html]. Accessed on: 22 November 2010.</ref>
*[http://www.ouhsc.edu/histology/Glass%20slides/75_16.jpg Megakaryocyte (ouhsc.edu)].<ref>URL: [http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html]. Accessed on: 22 November 2010.</ref>


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===General===
===General===
*In adults it is a compensatory mechanism for [[bone marrow]] dysfunction.
*In adults it is a compensatory mechanism for [[bone marrow]] dysfunction.
Cause:
*Any process that disrupts the bone marrow, e.g. [[fibrous dysplasia]].


Locations:<ref>URL: [http://path.upmc.edu/cases/case283/dx.html http://path.upmc.edu/cases/case283/dx.html]. Accessed on: 14 January 2012.</ref>
Locations:<ref>URL: [http://path.upmc.edu/cases/case283/dx.html http://path.upmc.edu/cases/case283/dx.html]. Accessed on: 14 January 2012.</ref>
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**Make platelets.
**Make platelets.


Images:
====Images====
*[[WC]]:
<gallery>
**[http://commons.wikimedia.org/wiki/File:Nucleated_red_blood_cells_-_endometrial_polyp_-_high_mag.jpg Nucleated RBC - high mag. (WC)].
Image:Nucleated_red_blood_cells_-_endometrial_polyp_-_high_mag.jpg | Nucleated RBC - high mag. (WC)
*www:
</gallery>
**[http://path.upmc.edu/cases/case283.html EMH - several images (upmc.edu)].
www:
*[http://path.upmc.edu/cases/case283.html EMH - several images (upmc.edu)].
*[http://path.upmc.edu/cases/case690.html EMH - another case with several images (upmc.edu)].


==See also==
==See also==
*[[Haematopathology]].
*[[Haematopathology]].
*[[Bone]].
*[[Bone]].
*[[Bone marrow]].


==References==
==References==

Latest revision as of 15:27, 31 August 2014

Haematopoiesis is the making of blood. Problems in haematopoiesis are numberous and the domain of hematology and hematopathology.

Normal haematopoiesis

Microscopic

One should see three cell lines:[1]

  • Erythroid cells.
  • Myeloid cells.
  • Megakaryocytes.

Images

www:

Extramedullary haematopoiesis

  • Abbreviated EMH.

General

  • In adults it is a compensatory mechanism for bone marrow dysfunction.

Cause:

Locations:[3]

Microscopic

Features:

  • Erythroid cells - esp. nucleated red blood cells.
  • Myeloid - granulocytes and granulocyte precursors.
  • Megakaryocytes - Large cells (50-100 μm) with abundant cytoplasm.
    • Make platelets.

Images

www:

See also

References

  1. URL: http://emedicine.medscape.com/article/199003-overview. Accessed on: 22 November 2010.
  2. URL: http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html. Accessed on: 22 November 2010.
  3. URL: http://path.upmc.edu/cases/case283/dx.html. Accessed on: 14 January 2012.

External links