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Difference between revisions of "Haematopoiesis"
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'''Haematopoiesis''' making blood. | '''Haematopoiesis''' is the making of blood. Problems in haematopoiesis are numberous and the domain of hematology and [[hematopathology]]. | ||
==Normal haematopoiesis== | |||
===Microscopic=== | |||
One should see three cell lines:<ref>URL: [http://emedicine.medscape.com/article/199003-overview http://emedicine.medscape.com/article/199003-overview]. Accessed on: 22 November 2010.</ref> | One should see three cell lines:<ref>URL: [http://emedicine.medscape.com/article/199003-overview http://emedicine.medscape.com/article/199003-overview]. Accessed on: 22 November 2010.</ref> | ||
*Erythroid | *Erythroid cells. | ||
*Myeloid | *Myeloid cells. | ||
* | *Megakaryocytes. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Extramedullary_haematopoiesis_-_endometrial_polyp_-_high_mag.jpg | Nucleated RBCs - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.ouhsc.edu/histology/Glass%20slides/75_16.jpg Megakaryocyte (ouhsc.edu)].<ref>URL: [http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html]. Accessed on: 22 November 2010.</ref> | *[http://www.ouhsc.edu/histology/Glass%20slides/75_16.jpg Megakaryocyte (ouhsc.edu)].<ref>URL: [http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html http://www.ouhsc.edu/histology/Text%20Sections/Hematopoiesis.html]. Accessed on: 22 November 2010.</ref> | ||
==Extramedullary haematopoiesis== | |||
*Abbreviated ''EMH''. | |||
===General=== | |||
*In adults it is a compensatory mechanism for [[bone marrow]] dysfunction. | |||
Cause: | |||
*Any process that disrupts the bone marrow, e.g. [[fibrous dysplasia]]. | |||
Locations:<ref>URL: [http://path.upmc.edu/cases/case283/dx.html http://path.upmc.edu/cases/case283/dx.html]. Accessed on: 14 January 2012.</ref> | |||
*[[Liver]]. | |||
*[[Spleen]]. | |||
*[[Lymph node]]s. | |||
===Microscopic=== | |||
Features: | |||
*Erythroid cells - esp. nucleated red blood cells. | |||
*Myeloid - granulocytes and granulocyte precursors. | |||
*Megakaryocytes - Large cells (50-100 μm) with abundant cytoplasm. | |||
**Make platelets. | |||
====Images==== | |||
<gallery> | |||
Image:Nucleated_red_blood_cells_-_endometrial_polyp_-_high_mag.jpg | Nucleated RBC - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case283.html EMH - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case690.html EMH - another case with several images (upmc.edu)]. | |||
==See also== | ==See also== | ||
*[[Haematopathology]]. | *[[Haematopathology]]. | ||
*[[Bone]]. | *[[Bone]]. | ||
*[[Bone marrow]]. | |||
==References== | ==References== | ||