Difference between revisions of "HPFitis"

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'''HPFitis''' is use of ''HPF'' (high-power field) without qualification.
'''HPFitis''' is use of ''HPF'' (high-power field) without proper qualification, i.e. without giving the field area.  


''HPF'' redirects here.
===Etiology===
Its etiology is thought to be either:
Its etiology is thought to be either:
#Ignorance of statistics and sampling theory.
#Ignorance of statistics and sampling theory.
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It appears to have a higher incidence in math phobic individuals.
It appears to have a higher incidence in math phobic individuals.
===Consequences of HPFitis===
*Papers on [[eosinophilic esophagitis]] are ''not'' comparable.<ref name=pmid17617209>{{cite journal |author=Dellon ES, Aderoju A, Woosley JT, Sandler RS, Shaheen NJ |title=Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review |journal=Am. J. Gastroenterol. |volume=102 |issue=10 |pages=2300–13 |year=2007 |month=October |pmid=17617209 |doi=10.1111/j.1572-0241.2007.01396.x |url=}}</ref>
*[[GIST]]s were improperly [[cancer staging|staged]] - until they standardized to 5 mm<sup>2</sup>.
*Mitotic score in the Nottingham score for [[invasive breast cancer]] is based on the pseudo-standard area of "10 HPFs"; this results in significant variance due to the field area of the microscope in large cohorts.<ref name=pmid28202066>{{Cite journal  | last1 = Bonert | first1 = M. | last2 = Tate | first2 = AJ. | title = Mitotic counts in breast cancer should be standardized with a uniform sample area. | journal = Biomed Eng Online | volume = 16 | issue = 1 | pages = 28 | month = Feb | year = 2017 | doi = 10.1186/s12938-016-0301-z | pmc = 5312435 | PMID = 28202066 }}</ref>
===Field area===
Most modern [[microscope]]s, have an eye piece diameter of 22 mm. Therefore, the field diameter at 40 X is approximately 22 mm / 40 X ~= 0.55 mm and the field of view is pi/4*(0.55 mm)<sup>2</sup> = 0.2376 mm<sup>2</sup>.


==See also==
==See also==
*[[LPFitis]] - a related less common disease.
*[[IPFitis]] - a related uncommon disease.
*[[Basics]].
*[[Basics]].
==References==
{{Reflist|1}}


[[Category:Rants]]
[[Category:Rants]]

Latest revision as of 14:52, 26 November 2021

HPFitis is use of HPF (high-power field) without proper qualification, i.e. without giving the field area.

HPF redirects here.

Etiology

Its etiology is thought to be either:

  1. Ignorance of statistics and sampling theory.
  2. Laziness.
  3. A combination of the above two.

It appears to have a higher incidence in math phobic individuals.

Consequences of HPFitis

  • Papers on eosinophilic esophagitis are not comparable.[1]
  • GISTs were improperly staged - until they standardized to 5 mm2.
  • Mitotic score in the Nottingham score for invasive breast cancer is based on the pseudo-standard area of "10 HPFs"; this results in significant variance due to the field area of the microscope in large cohorts.[2]

Field area

Most modern microscopes, have an eye piece diameter of 22 mm. Therefore, the field diameter at 40 X is approximately 22 mm / 40 X ~= 0.55 mm and the field of view is pi/4*(0.55 mm)2 = 0.2376 mm2.

See also

References

  1. Dellon ES, Aderoju A, Woosley JT, Sandler RS, Shaheen NJ (October 2007). "Variability in diagnostic criteria for eosinophilic esophagitis: a systematic review". Am. J. Gastroenterol. 102 (10): 2300–13. doi:10.1111/j.1572-0241.2007.01396.x. PMID 17617209.
  2. Bonert, M.; Tate, AJ. (Feb 2017). "Mitotic counts in breast cancer should be standardized with a uniform sample area.". Biomed Eng Online 16 (1): 28. doi:10.1186/s12938-016-0301-z. PMC 5312435. PMID 28202066. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312435/.