Glomus tumour

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Glomus tumours, AKA glomangioma, are painful.

It should not be confused with paraganglioma, which were once called glomus tumour.

General

  • Tumour derived from smooth muscle cell.[1]
  • Usually benign.
    • Malignant variant exists - extremely rare.

Clinical:

Microscopic

Features:[2]

  • Sheets of equally-spaced cells ("cookie cutter appearance") - key feature.
  • Polygonal cells with identifiable cellular borders.
  • Thin-walled blood vessels.
  • Moderate clear cytoplasm.

Notes:

  • No significant nuclear atypia.
  • The regular cell spacing is called "cookie cutter appearance". It looks like the cells were created with a cookie cutter; the spacing between cell is equal and they all look very similar.

Images:

IHC

Features:[3]

  • SMA +ve ~ 100%.
  • Desmin usu. -ve.
  • CD34 -ve.
    • Rarely +ve.

Others:

  • S100 -ve.

Other diagnoses...

Why it is not a(n) ...[2]

See also

References

  1. Gombos Z, Zhang PJ (September 2008). "Glomus tumor". Arch. Pathol. Lab. Med. 132 (9): 1448–52. doi:10.1043/1543-2165(2008)132[1448:GT]2.0.CO;2. PMID 18788860.
  2. 2.0 2.1 URL: http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/Z0B003-PQ01-M.htm. Accessed on: 19 October 2010.
  3. Hatori M, Aiba S, Kato M, Kamiya N, Kokubun S (July 1997). "Expression of CD34 in glomus tumors". Tohoku J. Exp. Med. 182 (3): 241–7. PMID 9362106.