Difference between revisions of "Glassy cell carcinoma"

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{{ Infobox diagnosis
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| Name      = {{PAGENAME}}
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| Image      = Glassy_cell_carcinoma_-_high_mag.jpg
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| Width      =
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| Caption    = Glassy cell carcinoma. [[H&E stain]].
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| Synonyms  =
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| Micro      = epithelioid cells in sheets or cords with a round/oval nucleus, one or more prominent nucleoli, abundant finely vacuolated eosinophilic to amphophilic cytoplasm, distinct cell borders, inflammation - especially eosinophils
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| Subtypes  =
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| LMDDx      = [[Adenosquamous carcinoma|adenosquamous carcinoma of the uterine cervix]], [[squamous carcinoma of the uterine cervix]]
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| Stains    = [[PAS stain]] +ve (plasma membrane)
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| IHC        =
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| EM        =
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| Molecular  =
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| IF        =
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| Gross      =
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| Grossing  =
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| Site      = [[uterine cervix]]
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| Assdx      =
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| Syndromes  =
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| Clinicalhx = rapid growth
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| Signs      =
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| Symptoms  =
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| Prevalence = rare
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| Bloodwork  =
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| Rads      =
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| Endoscopy  =
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| Prognosis  = poor
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| Other      =
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| ClinDDx    = other [[uterine cervix|cervical]] tumours
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| Tx        =
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}}
 
'''Glassy cell carcinoma''', abbreviated '''GCC''', is a rare [[malignancy]] of the [[uterine cervix]].
 
'''Glassy cell carcinoma''', abbreviated '''GCC''', is a rare [[malignancy]] of the [[uterine cervix]].
  
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==Microscopic==
 
==Microscopic==
 
Features:<ref name=pmid11393075>{{Cite journal  | last1 = Reis-Filho | first1 = JS. | last2 = Fillus Neto | first2 = J. | last3 = Schonemann | first3 = E. | last4 = Sanderson | first4 = A. | last5 = Schmitt | first5 = FC. | title = Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. | journal = Acta Cytol | volume = 45 | issue = 3 | pages = 407-10 | month =  | year =  | doi =  | PMID = 11393075 }}</ref>
 
Features:<ref name=pmid11393075>{{Cite journal  | last1 = Reis-Filho | first1 = JS. | last2 = Fillus Neto | first2 = J. | last3 = Schonemann | first3 = E. | last4 = Sanderson | first4 = A. | last5 = Schmitt | first5 = FC. | title = Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study. | journal = Acta Cytol | volume = 45 | issue = 3 | pages = 407-10 | month =  | year =  | doi =  | PMID = 11393075 }}</ref>
*Epithelioid cells in sheets or cords.
+
*Epithelioid cells in sheets or cords with:
*Round/oval nucleus.
+
**Round/oval nucleus.
*One or more prominent nucleoli.
+
**One or more prominent nucleoli.
*Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
+
**Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
*Distinct cell borders.  
+
**Distinct cell borders.  
 
*Inflammation - esp. eosinophils.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=561 http://www.webpathology.com/image.asp?n=2&Case=561]. Accessed on: 4 September 2011.</ref>
 
*Inflammation - esp. eosinophils.<ref>URL: [http://www.webpathology.com/image.asp?n=2&Case=561 http://www.webpathology.com/image.asp?n=2&Case=561]. Accessed on: 4 September 2011.</ref>
  

Revision as of 02:30, 25 April 2014

Glassy cell carcinoma
Diagnosis in short

Glassy cell carcinoma. H&E stain.

LM epithelioid cells in sheets or cords with a round/oval nucleus, one or more prominent nucleoli, abundant finely vacuolated eosinophilic to amphophilic cytoplasm, distinct cell borders, inflammation - especially eosinophils
LM DDx adenosquamous carcinoma of the uterine cervix, squamous carcinoma of the uterine cervix
Stains PAS stain +ve (plasma membrane)
Site uterine cervix

Clinical history rapid growth
Prevalence rare
Prognosis poor
Clin. DDx other cervical tumours

Glassy cell carcinoma, abbreviated GCC, is a rare malignancy of the uterine cervix.

General

Microscopic

Features:[3]

  • Epithelioid cells in sheets or cords with:
    • Round/oval nucleus.
    • One or more prominent nucleoli.
    • Abundant finely vacuolated eosinophilic to amphophilic cytoplasm.
    • Distinct cell borders.
  • Inflammation - esp. eosinophils.[4]

DDx:

Images

www:

Stains

See also

References

  1. Nasu, K.; Takai, N.; Narahara, H. (Jun 2009). "Multimodal treatment for glassy cell carcinoma of the uterine cervix.". J Obstet Gynaecol Res 35 (3): 584-7. doi:10.1111/j.1447-0756.2008.00968.x. PMID 19527406.
  2. Kosińiska-Kaczyńska, K.; Mazanowska, N.; Bomba-Opoń, D.; Horosz, E.; Marczewska, M.; Wielgoś, M. (Dec 2011). "Glassy cell carcinoma of the cervix--a case report with review of the literature.". Ginekol Pol 82 (12): 936-9. PMID 22384631.
  3. Reis-Filho, JS.; Fillus Neto, J.; Schonemann, E.; Sanderson, A.; Schmitt, FC.. "Glassy cell carcinoma of the uterine cervix. Report of a case with cytohistologic and immunohistochemical study.". Acta Cytol 45 (3): 407-10. PMID 11393075.
  4. URL: http://www.webpathology.com/image.asp?n=2&Case=561. Accessed on: 4 September 2011.
  5. Deshpande, AH.; Kotwal, MN.; Bobhate, SK.. "Glassy cell carcinoma of the uterine cervix a rare histology. Report of three cases with a review of the literature.". Indian J Cancer 41 (2): 92-5. PMID 15318016.