Gastric xanthoma
Jump to navigation
Jump to search
The printable version is no longer supported and may have rendering errors. Please update your browser bookmarks and please use the default browser print function instead.
Gastric xanthoma | |
---|---|
Diagnosis in short | |
Gastric xanthoma. H&E stain. | |
| |
LM | gastric lamina propria with lipid-laden macrophages |
LM DDx | signet ring cell carcinoma, Whipple disease, MAI infection |
IHC | CD68 +ve, AE1/AE3 -ve |
Gross | yellowish nodule or plaque - usu. lesser curvature |
Site | stomach |
| |
Prevalence | uncommon |
Prognosis | benign |
Gastric xanthoma, abbreviated GX, is an uncommon benign lesion of the stomach.
It is also known as xanthelasma and stomach lipidosis.
General
- Uncommon.
- Benign.
Gross/endoscopic
Microscopic
Features:[1]
- Collections of lipid-laden macrophages within the gastric lamina propria.
DDx:
Images
www:
IHC
- CD68 +ve.
- Panker (AE1/AE3) -ve.
- To exclude carcinoma.
Sign out
Stomach, Cardia Lesion, Biopsy: - Polypoid gastric xanthoma. - NEGATIVE for Helicobacter-like organisms. - NEGATIVE for intestinal metaplasia. - NEGATIVE for dysplasia and NEGATIVE for malignancy. Comment: The histiocytes in were demonstrated with a CD68 immunostain. An AE1/AE3 immunostain and a Ki-67 immunostain have a benign pattern.
See also
References
- ↑ 1.0 1.1 Iacobuzio-Donahue, Christine A.; Montgomery, Elizabeth A. (2005). Gastrointestinal and Liver Pathology: A Volume in the Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 111. ISBN 978-0443066573.
- ↑ 2.0 2.1 Drude, RB.; Balart, LA.; Herrington, JP.; Beckman, EN.; Burns, TW. (Jun 1982). "Gastric xanthoma: histologic similarity to signet ring cell carcinoma.". J Clin Gastroenterol 4 (3): 217-21. PMID 6284833.