Difference between revisions of "Fundic gland polyp"

Fundic gland polyp
	Diagnosis in short
LM DDx	hyperplastic polyp of the stomach
Site	stomach - usually fundus
Associated Dx	gastroesophageal reflux disease - thus PPI use
Syndromes	familial adenomatous polyposis
Prevalence	common
Endoscopy	polyps
Prognosis	benign
Clin. DDx	gastric adenoma, hyperplastic polyp of the stomach

Revision as of 14:43, 28 September 2013

Fundic gland polyp, abbreviated FGP, is a relatively common pathology of the stomach. It is associated with familial adenomatous polyposis and proton pump inhibitor use.

General

Most common stomach polyp.^[1]
Fundic location usually.
- May be in the body.^[1]

Clinical significance

Weak association with FAP (familial adenomatous polyposis).^[1]^[2]
Associated with chronic proton pump inhibitors (PPI) use -- approximately 4x risk.^[3]

Notes:

Animal studies suggested PPIs cause neuroendocrine tumours -- but this has not been found in humans.^[4]

Gross

Polyps.

Image:

FGP on endoscopy. (WC)

Microscopic

Features:^[5]

Polypoid shape (may not be appreciated on microscopy).
Dilated gastric glands.
- Flatted epithelial lining (consisting of normal foveolar epithelium) - key feature.

Notes:

The presence of dysplastic changes should prompt consideration of FAP.

DDx:

Hyperplastic polyp of the stomach - has foveolar hyperplasia, gland dilation may be present.

Images

FGP - low mag. (WC)
FGP - high mag. (WC)

www:

Fundic gland polyp (ouhsc.edu).

Sign out

POLYP, STOMACH, BIOPSY:
- FUNDIC GLAND POLYP.
- NEGATIVE FOR INTESTINAL METAPLASIA.
- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS.
- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.

References

↑ ^1.0 ^1.1 ^1.2 Spiegel, A.; Stein, P.; Patel, M.; Patel, R.; Lebovics, E. (Jan 2010). "A report of gastric fundic gland polyps.". Gastroenterol Hepatol (N Y) 6 (1): 45-8. PMID 20567540.
↑ Freeman HJ (March 2008). "Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis". World J. Gastroenterol. 14 (9): 1318-20. PMID 18322941. http://www.wjgnet.com/1007-9327/14/1318.asp.
↑ Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH (November 2006). "Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy". Aliment. Pharmacol. Ther. 24 (9): 1341-8. doi:10.1111/j.1365-2036.2006.03127.x. PMID 17059515.
↑ Masaoka T, Suzuki H, Hibi T (May 2008). "Gastric epithelial cell modality and proton pump inhibitor". J Clin Biochem Nutr 42 (3): 191-6. doi:10.3164/jcbn.2008028. PMC 2386521. PMID 18545640. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386521/.
↑ URL: http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm. Accessed on: 19 October 2010.

[pmid20567540-1] 1.0 ^1.1 ^1.2 Spiegel, A.; Stein, P.; Patel, M.; Patel, R.; Lebovics, E. (Jan 2010). "A report of gastric fundic gland polyps.". Gastroenterol Hepatol (N Y) 6 (1): 45-8. PMID 20567540.

[pmid18322941-2] Freeman HJ (March 2008). "Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis". World J. Gastroenterol. 14 (9): 1318-20. PMID 18322941. http://www.wjgnet.com/1007-9327/14/1318.asp.

[3] Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH (November 2006). "Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy". Aliment. Pharmacol. Ther. 24 (9): 1341-8. doi:10.1111/j.1365-2036.2006.03127.x. PMID 17059515.

[4] Masaoka T, Suzuki H, Hibi T (May 2008). "Gastric epithelial cell modality and proton pump inhibitor". J Clin Biochem Nutr 42 (3): 191-6. doi:10.3164/jcbn.2008028. PMC 2386521. PMID 18545640. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386521/.

[5] URL: http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm. Accessed on: 19 October 2010.

[1]

[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
-#redirect [[Stomach#Fundic_gland_polyp]]
+{{ Infobox diagnosis
+| Name       = {{PAGENAME}}
+| Image      =
+| Width      =
+| Caption    =
+| Micro      =
+| Subtypes   =
+| LMDDx      = [[hyperplastic polyp of the stomach]]
+| Stains     =
+| IHC        =
+| EM         =
+| Molecular  =
+| IF         =
+| Gross      =
+| Grossing   =
+| Site       = [[stomach]] - usually fundus
+| Assdx      = [[gastroesophageal reflux disease]] - thus PPI use
+| Syndromes  = [[familial adenomatous polyposis]]
+| Clinicalhx =
+| Signs      =
+| Symptoms   =
+| Prevalence = common
+| Bloodwork  =
+| Rads       =
+| Endoscopy  = polyps
+| Prognosis  = benign
+| Other      =
+| ClinDDx    = [[gastric adenoma]], [[hyperplastic polyp of the stomach]]
+}}
+'''Fundic gland polyp''', abbreviated '''FGP''', is a relatively common pathology of the [[stomach]]. It is associated with [[familial adenomatous polyposis]] and proton pump inhibitor use.
+==General==
+*Most common stomach polyp.<ref name=pmid20567540/>
+*''Fundic'' location usually.
+**May be in the body.<ref name=pmid20567540>{{Cite journal  | last1 = Spiegel | first1 = A. | last2 = Stein | first2 = P. | last3 = Patel | first3 = M. | last4 = Patel | first4 = R. | last5 = Lebovics | first5 = E. | title = A report of gastric fundic gland polyps. | journal = Gastroenterol Hepatol  (N Y) | volume = 6 | issue = 1 | pages = 45-8 | month = Jan | year = 2010 | doi =  | PMID = 20567540 }}</ref>
+===Clinical significance===
+*Weak association with FAP ([[familial adenomatous polyposis]]).<ref name=pmid20567540/><ref name=pmid18322941>{{cite journal |author=Freeman HJ |title=Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis |journal=World J. Gastroenterol. |volume=14 |issue=9 |pages=1318-20 |year=2008 |month=March |pmid=18322941 |doi= |url=http://www.wjgnet.com/1007-9327/14/1318.asp}}</ref>
+*Associated with chronic proton pump inhibitors (PPI) use -- approximately 4x risk.<ref>{{cite journal |author=Jalving M, Koornstra JJ, Wesseling J, Boezen HM, DE Jong S, Kleibeuker JH |title=Increased risk of fundic gland polyps during long-term proton pump inhibitor therapy |journal=Aliment. Pharmacol. Ther. |volume=24 |issue=9 |pages=1341-8 |year=2006 |month=November |pmid=17059515 |doi=10.1111/j.1365-2036.2006.03127.x |url=}}</ref>
+Notes:
+*Animal studies suggested PPIs cause [[neuroendocrine tumour]]s -- but this has not been found in humans.<ref>{{cite journal |author=Masaoka T, Suzuki H, Hibi T |title=Gastric epithelial cell modality and proton pump inhibitor |journal=J Clin Biochem Nutr |volume=42 |issue=3 |pages=191-6 |year=2008 |month=May |pmid=18545640 |pmc=2386521 |doi=10.3164/jcbn.2008028 |url=}}</ref>
+==Gross==
+*Polyps.
+Image:
+<gallery>
+Image:Endoscopic_view_of_fundic_gland_polyps.jpg | FGP on endoscopy. (WC)
+</gallery>
+==Microscopic==
+Features:<ref>URL: [http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm]. Accessed on: 19 October 2010.</ref>
+*Polypoid shape (may not be appreciated on microscopy).
+*Dilated gastric glands.
+**Flatted epithelial lining (consisting of normal foveolar epithelium) - '''key feature'''.
+Notes:
+*The presence of dysplastic changes should prompt consideration of ''FAP''.
+DDx:
+*[[Hyperplastic polyp of the stomach]] - has foveolar hyperplasia, gland dilation may be present.
+===Images===
+<gallery>
+Image:Fundic gland polyp (1).jpg | FGP - low mag. (WC)
+Image:Fundic_gland_polyp_(2).jpg | FGP - high mag. (WC)
+</gallery>
+www:
+*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/A2B001-PQ01-M.htm Fundic gland polyp (ouhsc.edu)].
+==Sign out==
+<pre>
+POLYP, STOMACH, BIOPSY:
+- FUNDIC GLAND POLYP.
+- NEGATIVE FOR INTESTINAL METAPLASIA.
+- NEGATIVE FOR HELICOBACTER-LIKE ORGANISMS.
+- NEGATIVE FOR DYSPLASIA AND NEGATIVE FOR MALIGNANCY.
+</pre>
+==See also==
+*[[Stomach]].
+*[[Neuroendocrine tumours]].
+*[[Gastric columnar dysplasia]].
+==References==
+{{Reflist|2}}
+[[Category:Stomach]]
 [[Category:Diagnosis]]

Difference between revisions of "Fundic gland polyp"

Revision as of 14:43, 28 September 2013

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