Foregut primary carcinomas

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Foregut primary carcinomas can be difficult to definitively categorize on the basis of pathology alone, as their immunostaining patterns significantly overlap.[1]

Foregut primary directs to this article.

Foregut

The foregut includes the following:

IHC

Foregut carcinomas are typically:

  • CK7 +ve.
  • CK20 -ve.
  • CDX2 -ve.
  • HNF-1beta +ve (72-87% of cases +ve - in one study[3]).

A (query) foregut primary panel for liver lesions:

  • AE1/AE3, CK7, CK20, CK19, CDX2, HepPar-1, CA-125, GATA3, PAX8, WT-1, TTF-1.

See also

References

  1. Lee, MJ.; Lee, HS.; Kim, WH.; Choi, Y.; Yang, M. (May 2003). "Expression of mucins and cytokeratins in primary carcinomas of the digestive system.". Mod Pathol 16 (5): 403-10. doi:10.1097/01.MP.0000067683.84284.66. PMID 12748245.
  2. Jennings RE, Berry AA, Kirkwood-Wilson R, Roberts NA, Hearn T, Salisbury RJ, Blaylock J, Piper Hanley K, Hanley NA (October 2013). "Development of the human pancreas from foregut to endocrine commitment". Diabetes 62 (10): 3514–22. doi:10.2337/db12-1479. PMC 3781486. PMID 23630303. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781486/.
  3. Yang MX, Coates RF, Ambaye A, Gardner JA, Zubarick R, Gao Y, Skelly J, Liu JG, Mino-Kenudson M (2018). "Investigation of HNF-1B as a diagnostic biomarker for pancreatic ductal adenocarcinoma". Biomark Res 6: 25. doi:10.1186/s40364-018-0139-6. PMC 6062876. PMID 30065837. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062876/.