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Difference between revisions of "Foamy gland carcinoma"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg | |||
| Width = | |||
| Caption = Foamy gland carcinoma. [[H&E stain]]. | |||
| Synonyms = foamy gland adenocarcinoma | |||
| Micro = | |||
| Subtypes = (subtype of [[prostate carcinoma]]) | |||
| LMDDx = [[adenosis of the prostate]], [[bulbourethral gland]], [[pseudohyperplastic adenocarcinoma]] | |||
| Stains = | |||
| IHC = AMACR +ve, CK5/6 -ve, p63 -ve | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = see ''[[prostate carcinoma]]'' | |||
| Grossing = see ''[[prostate carcinoma]]'' | |||
| Staging = [[prostate cancer staging]] | |||
| Site = [[prostate gland]] - see ''[[prostate carcinoma]]'' | |||
| Assdx = | |||
| Syndromes = see ''[[prostate carcinoma]]'' | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = uncommon | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = often good, dependent on [[prostate cancer grading|grade]] & stage | |||
| Other = | |||
| ClinDDx = see ''[[prostate carcinoma]]'' | |||
| Tx = see ''[[prostate carcinoma]]'' | |||
}} | |||
'''Foamy gland carcinoma''', also '''foamy gland adenocarcinoma''',<ref name=pmid19033862/> is an uncommon variant of [[prostate carcinoma]] that has a bland appearance and may be confused with benign glands. | |||
==General== | |||
{{Main|Prostate_carcinoma#General| l1 = Prostate carcinoma}} | |||
*Rare. | |||
*Usually low grade, i.e. [[Gleason score]] 6/10.<ref name=pmid19033862>{{Cite journal | last1 = Zhao | first1 = J. | last2 = Epstein | first2 = JI. | title = High-grade foamy gland prostatic adenocarcinoma on biopsy or transurethral resection: a morphologic study of 55 cases. | journal = Am J Surg Pathol | volume = 33 | issue = 4 | pages = 583-90 | month = Apr | year = 2009 | doi = 10.1097/PAS.0b013e31818a5c6c | PMID = 19033862 }}</ref> | |||
==Microscopic== | |||
Features: | |||
*Increased glandular density - '''key feature'''. | |||
*Eosinophilic intraluminal amorphous secretions - '''key feature'''. | |||
*Abundant foamy cytoplasm. | |||
*Tufted glandular border. | |||
*Gland size larger than "typical" prostate cancer. | |||
Note: | |||
*Prominent [[nucleoli]] usually infrequent ''or'' absent!<ref name=pmid19033862/> | |||
*Can be thought of as [[pseudohyperplastic adenocarcinoma]] without the nucleoli. | |||
DDx: | |||
*[[Adenosis of the prostate]]. | |||
*[[Bulbourethral gland]]. | |||
===Images=== | |||
<gallery> | |||
Image: Intraluminal eosinophilic crystalloid of prostate gland - high mag.jpg | Intraluminal eosinophilic crystalloid in foamy glands. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.nature.com/modpathol/journal/v17/n3/fig_tab/3800050f11.html#figure-title Foamy gland carcinoma (nature.com)]. | |||
==See also== | |||
*[[Prostate carcinoma]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Prostate carcinoma]] | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||