Fibrosing pleuritis

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Fibrosing pleuritis, also fibrous pleurisy and fibrous pleuritis‎, is an uncommon benign condition that mimics malignant mesothelioma.

It may be referred to as cryptogenic bilateral fibrosing pleuritis, if it is bilateral.

General

  • Benign.
  • No asbestos exposure.[1]

Clinical:[1]

Gross

Microscopic

Features:[citation needed]

  • Fibrosis.
    • Spindle cells.
    • Moderate cellularity.
  • No necrosis.[2]
  • Inflammation - lymphocytes.[1]

DDx:[3]

IHC

  • p53 -ve/+ve.
    • More common in mesothelioma.[2]

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Pleura, Left Lung, Biopsy:
- Fibrous pleuritis (fibrous tissue with mild chronic inflammation and calcifications).
- NEGATIVE for malignancy.

See also

References

  1. 1.0 1.1 1.2 Buchanan, DR.; Johnston, ID.; Kerr, IH.; Hetzel, MR.; Corrin, B.; Turner-Warwick, M. (Apr 1988). "Cryptogenic bilateral fibrosing pleuritis.". Br J Dis Chest 82 (2): 186-93. PMID 3166932.
  2. 2.0 2.1 Mangano, WE.; Cagle, PT.; Churg, A.; Vollmer, RT.; Roggli, VL. (Aug 1998). "The diagnosis of desmoplastic malignant mesothelioma and its distinction from fibrous pleurisy: a histologic and immunohistochemical analysis of 31 cases including p53 immunostaining.". Am J Clin Pathol 110 (2): 191-9. PMID 9704618.
  3. Corson, JM. (Nov 2004). "Pathology of mesothelioma.". Thorac Surg Clin 14 (4): 447-60. doi:10.1016/j.thorsurg.2004.06.007. PMID 15559051.