Difference between revisions of "Epithelial-myoepithelial carcinoma"

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*Rare ~1% of salivary gland tumours.<ref  name=pmid9568184>{{Cite journal  | last1 = Tralongo | first1 = V. | last2 = Daniele | first2 = E. | title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. | journal = Anticancer Res | volume = 18 | issue = 1B | pages = 603-8 | month =  | year =  | doi =  | PMID = 9568184 }}</ref>
*Rare ~1% of salivary gland tumours.<ref  name=pmid9568184>{{Cite journal  | last1 = Tralongo | first1 = V. | last2 = Daniele | first2 = E. | title = Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. | journal = Anticancer Res | volume = 18 | issue = 1B | pages = 603-8 | month =  | year =  | doi =  | PMID = 9568184 }}</ref>
*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal  | last1 = Seethala | first1 = RR. | last2 = Barnes | first2 = EL. | last3 = Hunt | first3 = JL. | title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. | journal = Am J Surg Pathol | volume = 31 | issue = 1 | pages = 44-57 | month = Jan | year = 2007 | doi = 10.1097/01.pas.0000213314.74423.d8 | PMID = 17197918 }}</ref>
*Female:male = 1.5:1.<ref name=pmid17197918>{{Cite journal  | last1 = Seethala | first1 = RR. | last2 = Barnes | first2 = EL. | last3 = Hunt | first3 = JL. | title = Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. | journal = Am J Surg Pathol | volume = 31 | issue = 1 | pages = 44-57 | month = Jan | year = 2007 | doi = 10.1097/01.pas.0000213314.74423.d8 | PMID = 17197918 }}</ref>
*Usu. older people - 50s or 60s.
*Usually older people - 50s or 60s.
*Usu. parotid gland ~ 60% of cases.<ref name=pmid17197918/>
*Usually parotid gland ~ 60% of cases.<ref name=pmid17197918/>
**An analogous lung tumour exists - see ''[[epithelial-myoepithelial carcinoma of lung]].<ref>{{Cite journal  | last1 = Nakashima | first1 = Y. | last2 = Morita | first2 = R. | last3 = Ui | first3 = A. | last4 = Iihara | first4 = K. | last5 = Yazawa | first5 = T. | title = Epithelial-myoepithelial carcinoma of the lung: a case report. | journal = Surg Case Rep | volume = 4 | issue = 1 | pages = 74 | month = Jul | year = 2018 | doi = 10.1186/s40792-018-0482-8 | PMID = 29987577 }}</ref>
*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>
*Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.<ref name=pmid17197918/>



Revision as of 00:16, 18 March 2019

Epithelial-myoepithelial carcinoma
Diagnosis in short

Epithelial-myoepithelial carcinoma. H&E stain.

LM biphasic tumour with (1) epithelial layer, and (2) myoepithelial layer; variable architecture (solid, cystic, tubular, papillary); +/- spindle cells
LM DDx adenoid cystic carcinoma (tubular variant), pleomorphic adenoma, tubular variant.
IHC CAM5.2 +ve (epithelial comp.), p63 +ve (myoepithelial comp.)
Site salivary gland - usually parotid gland

Signs salivary gland mass
Prevalence very rare
Clin. DDx other salivary gland masses

Epithelial-myoepithelial carcinoma, abbreviated EMCa, is a rare malignant salivary gland tumour.

General

  • Rare ~1% of salivary gland tumours.[1]
  • Female:male = 1.5:1.[2]
  • Usually older people - 50s or 60s.
  • Usually parotid gland ~ 60% of cases.[2]
  • Prognosis: usually good; 5-year and 10-year survival over 90% and 80% respectively.[2]

Notes:

Microscopic

Features:

  • Biphasic tumour:[2]
    1. Epithelial layer.
    2. Myoepithelial layer - key feature.
  • Architecture: variable (solid, cystic, tubular, papillary).
  • +/-Spindle cells.
  • Basement membrane-like material; may mimic adenoid cystic carcinoma.

Notes:

  • Usually few mitoses.

DDx:

Images

www:

IHC

  • CAM5.2 +ve -- epithelial component.
  • p63 +ve -- myoepithelial component.

See also

References

  1. Tralongo, V.; Daniele, E.. "Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature.". Anticancer Res 18 (1B): 603-8. PMID 9568184.
  2. 2.0 2.1 2.2 2.3 Seethala, RR.; Barnes, EL.; Hunt, JL. (Jan 2007). "Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract.". Am J Surg Pathol 31 (1): 44-57. doi:10.1097/01.pas.0000213314.74423.d8. PMID 17197918.
  3. Nakashima, Y.; Morita, R.; Ui, A.; Iihara, K.; Yazawa, T. (Jul 2018). "Epithelial-myoepithelial carcinoma of the lung: a case report.". Surg Case Rep 4 (1): 74. doi:10.1186/s40792-018-0482-8. PMID 29987577.
  4. Seifert, G. (Sep 1998). "Are adenomyoepithelioma of the breast and epithelial-myoepithelial carcinoma of the salivary glands identical tumours?". Virchows Arch 433 (3): 285-8. PMID 9769134.
  5. [http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html "Cytopathologic Features of Epithelial-myoepithelial Carcinoma"]. http://www.pathologyimagesinc.com/sgt-cytopath/epith-myoepith-ca/cytopathology/fs-emc-cytopath-feat.html. Retrieved January 18, 2011.