Difference between revisions of "Epilepsy"

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→‎Microscopic: Hippocampal sclerosis
(→‎Microscopic: Hippocampal sclerosis)
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*[[Ganglioglioma]].<ref name=pmid12125968>{{Cite journal  | last1 = Im | first1 = SH. | last2 = Chung | first2 = CK. | last3 = Cho | first3 = BK. | last4 = Lee | first4 = SK. | title = Supratentorial ganglioglioma and epilepsy: postoperative seizure outcome. | journal = J Neurooncol | volume = 57 | issue = 1 | pages = 59-66 | month = Mar | year = 2002 | doi =  | PMID = 12125968 }}</ref>
*[[Ganglioglioma]].<ref name=pmid12125968>{{Cite journal  | last1 = Im | first1 = SH. | last2 = Chung | first2 = CK. | last3 = Cho | first3 = BK. | last4 = Lee | first4 = SK. | title = Supratentorial ganglioglioma and epilepsy: postoperative seizure outcome. | journal = J Neurooncol | volume = 57 | issue = 1 | pages = 59-66 | month = Mar | year = 2002 | doi =  | PMID = 12125968 }}</ref>


==Microscopic==
==Types==
Features:<ref>MUN. 15 November 2010.</ref>
Features:<ref>MUN. 15 November 2010.</ref>
*Temporal lobe epilepsy
*Mesial temporal sclerosis = scarring of the medial temporal lobe.
*Mesial temporal sclerosis = scarring of the medial temporal lobe.
**Involves: hippocampus, parahippocampal gyrus and amygdala.
**Involves: hippocampus, parahippocampal gyrus and amygdala.
***Hippocampus: CA1 and CA4 affected.
 
===Hippocampal sclerosis===
*Most frequent histopathology in temporal lobe epilepsy (33% of all epilepsy surgery specimen).
*ILAE classification for hippocampus specimen:<ref>{{Cite journal  | last1 = Blümcke | first1 = I. | last2 = Thom | first2 = M. | last3 = Aronica | first3 = E. | last4 = Armstrong | first4 = DD. | last5 = Bartolomei | first5 = F. | last6 = Bernasconi | first6 = A. | last7 = Bernasconi | first7 = N. | last8 = Bien | first8 = CG. | last9 = Cendes | first9 = F. | title = International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. | journal = Epilepsia | volume = 54 | issue = 7 | pages = 1315-29 | month = Jul | year = 2013 | doi = 10.1111/epi.12220 | PMID = 23692496 }}</ref>
** ILAE type 1: cell loss predominantly in  CA1 and CA4 sectors.
** ILAE type 2: predominant CA1 neuron loss and gliosis.
** ILAE type 3: CA4 predominant neuronal cell loss and gliosis.
 
Clinic:
ILAE type 1: benefit from epilepsy surgery.  


Notes:
Notes:
*Changes in CA1 & CA4 of the hippocampus - DDx:
*Gliosis withot neuronal loss is not considered hippocampal sclerosis.
 
DDx:
**Epilepsy.
**Epilepsy.
**[[Dementia]].
**[[Dementia]].
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