Difference between revisions of "Endosalpingiosis"

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#redirect [[Gynecologic pathology#Endosalpingiosis]]
{{ Infobox diagnosis
| Name      = {{PAGENAME}}
| Image      = Endosalpingiosis_-_high_mag.jpg
| Width      =
| Caption    = Endosalpingiosis. [[H&E stain]].
| Micro      = cystic lesion with ciliated epithelium surrounded by fibrous stroma, [[psammoma bodies]]
| Subtypes  =
| LMDDx      = [[endometriosis]], [[serous carcinoma]], [[adenocarcinoma]], [[peritoneal inclusion cyst]]
| Stains    =
| IHC        = CK7 +ve, WT-1 +ve, CA125 +ve
| EM        =
| Molecular  =
| IF        =
| Gross      =
| Grossing  =
| Site      = [[peritoneum]], [[omentum]], [[lymph node]] (rare)
| Assdx      =
| Syndromes  =
| Clinicalhx = may be associated with endometriosis; incidental finding
| Signs      =
| Symptoms  =
| Prevalence =
| Bloodwork  =
| Rads      =
| Endoscopy  =
| Prognosis  = benign
| Other      =
| ClinDDx    =
}}
'''Endosalpingiosis''' is a benign entity that can be confused for [[cancer]].
 
==General==
*Benign entity that may lead to a misdiagnosis of [[adenocarcinoma]]<ref name=pmid19415948>{{cite journal |author=Lin O |title=Challenges in the interpretation of peritoneal cytologic specimens |journal=Arch. Pathol. Lab. Med. |volume=133 |issue=5 |pages=739–42 |year=2009 |month=May |pmid=19415948 |doi= |url=}}</ref> or [[serous carcinoma]].
*The clinical significance of endosalpingiosis is not definitively settled; opinions differ on whether it is:
*# associated with pelvic pain,<ref name=pmid9350013>{{Cite journal  | last1 = deHoop | first1 = TA. | last2 = Mira | first2 = J. | last3 = Thomas | first3 = MA. | title = Endosalpingiosis and chronic pelvic pain. | journal = J Reprod Med | volume = 42 | issue = 10 | pages = 613-6 | month = Oct | year = 1997 | doi =  | PMID = 9350013 }}</ref> ''or''
*# an incidental finding discovered in the course of investigating something else (pelvic pain, menstrual irregularities, infertility).<ref name=pmid12039470>{{Cite journal  | last1 = Heinig | first1 = J. | last2 = Gottschalk | first2 = I. | last3 = Cirkel | first3 = U. | last4 = Diallo | first4 = R. | title = Endosalpingiosis-an underestimated cause of chronic pelvic pain or an accidental finding? A retrospective study of 16 cases. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 103 | issue = 1 | pages = 75-8 | month = Jun | year = 2002 | doi =  | PMID = 12039470 }}</ref>
 
==Microscopic==
Features:<ref>URL: [http://radiographics.rsna.org/content/29/2/347.full http://radiographics.rsna.org/content/29/2/347.full]. Accessed on: 27 May 2010.</ref>
*Cystic lesions with:
**Ciliated (tubal type) epithelium, without endometrial stroma.
***Endosalpingiosis is surrounded by fibrous stroma; tubal type epithelial surrounded by ovarian stroma is a variant of [[endometriosis]].
*Associated with [[psammoma bodies]].<ref name=pmid1774734>{{cite journal |author=Hallman KB, Nahhas WA, Connelly PJ |title=Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report |journal=J Reprod Med |volume=36 |issue=9 |pages=675–8 |year=1991 |month=September |pmid=1774734 |doi= |url=}}</ref>
 
Notes:
#Not associated with hemorrhage.<ref>URL: [http://radiographics.rsna.org/content/29/2/347.full http://radiographics.rsna.org/content/29/2/347.full]. Accessed on: 27 May 2010.</ref>
#In a lymph node, endosalpingiosis may be misinterpreted as a [[lymph node metastasis|metastasis]]!<ref name=pmid20631604>{{Cite journal  | last1 = Corben | first1 = AD. | last2 = Nehhozina | first2 = T. | last3 = Garg | first3 = K. | last4 = Vallejo | first4 = CE. | last5 = Brogi | first5 = E. | title = Endosalpingiosis in axillary lymph nodes: a possible pitfall in the staging of patients with breast carcinoma. | journal = Am J Surg Pathol | volume = 34 | issue = 8 | pages = 1211-6 | month = Aug | year = 2010 | doi = 10.1097/PAS.0b013e3181e5e03e | PMID = 20631604 }}</ref>
 
DDx:<ref name=pmid20931212>{{Cite journal  | last1 = Rosenberg | first1 = P. | last2 = Nappi | first2 = L. | last3 = Santoro | first3 = A. | last4 = Bufo | first4 = P. | last5 = Greco | first5 = P. | title = Pelvic mass-like florid cystic endosalpingiosis of the uterus: a case report and a review of literature. | journal = Arch Gynecol Obstet | volume = 283 | issue = 3 | pages = 519-23 | month = Mar | year = 2011 | doi = 10.1007/s00404-010-1700-1 | PMID = 20931212 }}</ref>
*[[Serous carcinoma]].
*[[Peritoneal inclusion cyst]].
*[[Adenocarcinoma]].
*Papillary carcinoma.
 
===Images===
<gallery>
Image:Endosalpingiosis_-_low_mag.jpg | Endosalpingiosis -  low mag. (WC/Nephron)
Image:Endosalpingiosis_-_high_mag.jpg | Endosalpingiosis - high mag. (WC/Nephron)
Image:Endosalpingiosis_-_cropped_2_-_very_high_mag.jpg | Endosalpingiosis - very high mag. (WC/Nephron)
Image:Endosalpingiosis_in_lymph_node_-_intermed_mag.jpg | Endosalpingiosis in a LN - intermed. mag. (WC/Nephron)
Image:Endosalpingiosis_in_lymph_node_-_very_high_mag.jpg | Endosalpingiosis in a LN - very high mag. (WC/Nephron)
</gallery>
 
==IHC==
Features:<ref name=pmid21477174>{{cite journal |author=Stolnicu S, Preda O, Kinga S, ''et al.'' |title=Florid, papillary endosalpingiosis of the axillary lymph nodes |journal=Breast J |volume=17 |issue=3 |pages=268–72 |year=2011 |pmid=21477174 |doi=10.1111/j.1524-4741.2011.01081.x |url=}}</ref>
*CK7 +ve.
*WT-1 +ve.
*CA125 +ve.
 
==Sign out==
<pre>
OVARIAN FOSSA, RIGHT, BIOPSY:
- ENDOMETRIOSIS.
- ENDOSALPINGIOSIS.
- FIBROADIPOSE TISSUE PARTIALLY COVERED BY MESOTHELIUM.
</pre>
 
==See also==
*[[Gynecologic pathology]].
*[[Endometriosis]].
 
==References==
{{Reflist|2}}
 
[[Category:Diagnosis]]
[[Category:Gynecologic pathology]]

Latest revision as of 11:33, 2 July 2014

Endosalpingiosis
Diagnosis in short

Endosalpingiosis. H&E stain.
LM cystic lesion with ciliated epithelium surrounded by fibrous stroma, psammoma bodies
LM DDx endometriosis, serous carcinoma, adenocarcinoma, peritoneal inclusion cyst
IHC CK7 +ve, WT-1 +ve, CA125 +ve
Site peritoneum, omentum, lymph node (rare)
Clinical history may be associated with endometriosis; incidental finding
Prognosis benign

Endosalpingiosis is a benign entity that can be confused for cancer.

General

  • Benign entity that may lead to a misdiagnosis of adenocarcinoma[1] or serous carcinoma.
  • The clinical significance of endosalpingiosis is not definitively settled; opinions differ on whether it is:
    1. associated with pelvic pain,[2] or
    2. an incidental finding discovered in the course of investigating something else (pelvic pain, menstrual irregularities, infertility).[3]

Microscopic

Features:[4]

  • Cystic lesions with:
    • Ciliated (tubal type) epithelium, without endometrial stroma.
      • Endosalpingiosis is surrounded by fibrous stroma; tubal type epithelial surrounded by ovarian stroma is a variant of endometriosis.
  • Associated with psammoma bodies.[5]

Notes:

  1. Not associated with hemorrhage.[6]
  2. In a lymph node, endosalpingiosis may be misinterpreted as a metastasis![7]

DDx:[8]

Images

  • Endosalpingiosis - low mag. (WC/Nephron)

  • Endosalpingiosis - high mag. (WC/Nephron)

  • Endosalpingiosis - very high mag. (WC/Nephron)

  • Endosalpingiosis in a LN - intermed. mag. (WC/Nephron)

  • Endosalpingiosis in a LN - very high mag. (WC/Nephron)

IHC

Features:[9]

  • CK7 +ve.
  • WT-1 +ve.
  • CA125 +ve.

Sign out

OVARIAN FOSSA, RIGHT, BIOPSY:
- ENDOMETRIOSIS.
- ENDOSALPINGIOSIS.
- FIBROADIPOSE TISSUE PARTIALLY COVERED BY MESOTHELIUM.

See also

References

  1. ↑ Lin O (May 2009). "Challenges in the interpretation of peritoneal cytologic specimens". Arch. Pathol. Lab. Med. 133 (5): 739–42. PMID 19415948.
  2. ↑ deHoop, TA.; Mira, J.; Thomas, MA. (Oct 1997). "Endosalpingiosis and chronic pelvic pain.". J Reprod Med 42 (10): 613-6. PMID 9350013.
  3. ↑ Heinig, J.; Gottschalk, I.; Cirkel, U.; Diallo, R. (Jun 2002). "Endosalpingiosis-an underestimated cause of chronic pelvic pain or an accidental finding? A retrospective study of 16 cases.". Eur J Obstet Gynecol Reprod Biol 103 (1): 75-8. PMID 12039470.
  4. ↑ URL: http://radiographics.rsna.org/content/29/2/347.full. Accessed on: 27 May 2010.
  5. ↑ Hallman KB, Nahhas WA, Connelly PJ (September 1991). "Endosalpingiosis as a source of psammoma bodies in a Papanicolaou smear. A case report". J Reprod Med 36 (9): 675–8. PMID 1774734.
  6. ↑ URL: http://radiographics.rsna.org/content/29/2/347.full. Accessed on: 27 May 2010.
  7. ↑ Corben, AD.; Nehhozina, T.; Garg, K.; Vallejo, CE.; Brogi, E. (Aug 2010). "Endosalpingiosis in axillary lymph nodes: a possible pitfall in the staging of patients with breast carcinoma.". Am J Surg Pathol 34 (8): 1211-6. doi:10.1097/PAS.0b013e3181e5e03e. PMID 20631604.
  8. ↑ Rosenberg, P.; Nappi, L.; Santoro, A.; Bufo, P.; Greco, P. (Mar 2011). "Pelvic mass-like florid cystic endosalpingiosis of the uterus: a case report and a review of literature.". Arch Gynecol Obstet 283 (3): 519-23. doi:10.1007/s00404-010-1700-1. PMID 20931212.
  9. ↑ Stolnicu S, Preda O, Kinga S, et al. (2011). "Florid, papillary endosalpingiosis of the axillary lymph nodes". Breast J 17 (3): 268–72. doi:10.1111/j.1524-4741.2011.01081.x. PMID 21477174.
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