Difference between revisions of "Endometrial hyperplasia"

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Endometrial hyperplasia (view source)

Revision as of 03:04, 20 December 2013

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→‎Complex endometrial hyperplasia with atypia
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==Complex endometrial hyperplasia with atypia==
==Complex endometrial hyperplasia with atypia==
{{ Infobox external links
| Name          = Complex endometrial hyperplasia with atypia
| EHVSC          = 10181
| pathprotocols  =
| wikipedia      =
| pathoutlines  =
}}
*[[AKA]] ''complex atypical hyperplasia''.
*[[AKA]] ''complex atypical hyperplasia''.
===General===
{{Main|Complex endometrial hyperplasia}}
*High risk of transformation to [[endometrial carcinoma]].
 
===Microscopic===
Features:
*Increase in size & number of glands + irregular shape - '''key feature'''.
*Cell stratification.
*Nuclear enlargement.
*Nuclear atypia:
**Round nuclei ~ 2-3x the size of a lymphocyte.
**Grey/translucent chromatin.
**Nucleoli.
*Mitoses common.
 
Note:
*Atypical nuclei often hide between non-typical nuclei, like peg cells in the [[fallopian tube]].
 
DDx:
*[[Complex endometrial hyperplasia]].
*[[Endometrioid endometrial carcinoma]] - see ''[[endometrial carcinoma versus complex endometrial hyperplasia]]''.
 
Image:
*[http://www.webpathology.com/image.asp?n=2&Case=568 Complex endometrial hyperplasia with atypia (webpathology.com)].
 
===Sign out===
====Insufficient confluence for carcinoma====
<pre>
ENDOMETRIUM, BIOPSY:
- COMPLEX ENDOMETRIAL HYPERPLASIA WITH ATYPIA, SEE COMMENT.
 
COMMENT:
The sections show architecturally complex crowded glands with focal
morular squamous metaplasia and focal cribriforming.  Desmoplasia
is not identified. The degree of gland confluence is not considered
sufficient for the diagnosis of endometrial carcinoma. Nuclear atypia
is present focally.
</pre>
 
====Insufficient extent for carcinoma====
<pre>
ENDOMETRIUM, BIOPSY:
- COMPLEX ENDOMETRIAL HYPERPLASIA WITH ATYPIA, SEE COMMENT.
 
COMMENT:
The sections show architecturally complex back-to-back glands with focal
morular squamous metaplasia and cribriforming. Desmoplasia is not present.
The extent, i.e. the size of the abnormality, is not considered sufficient
for the diagnosis of endometrial carcinoma.
</pre>


=Other=
=Other=
Michael
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