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Difference between revisions of "Digital papillary adenocarcinoma"
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Digital papillary adenocarcinoma (view source)
Revision as of 17:36, 27 June 2014
, 17:36, 27 June 2014→Microscopic
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''' | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = aggressive digital papillary adenocarcinoma | |||
| Micro = | |||
| Subtypes = | |||
| LMDDx = [[basal cell carcinoma]], other basaloid tumours | |||
| Stains = | |||
| IHC = pankeratin +ve, CEA +ve (edge of ducts/spaces), EMA +ve (edge of ducts/spaces), S-100 +ve (luminal cells), SMA +ve (outer myoepithelial cell layer), p63 +ve (outer myoepithelial cell layer) | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[skin]] - digits (fingers or toes) | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = aggressive | |||
| Other = | |||
| ClinDDx = | |||
| Tx = ampuation | |||
}} | |||
'''Digital papillary adenocarcinoma''' (abbreviated '''DPA'''), also '''aggressive digital papillary adenocarcinoma''' (abbreviated '''ADPA'''), is a rare [[malignant]] [[skin]] tumour.<ref name=pmid23026931>{{cite journal |author=Suchak R, Wang WL, Prieto VG, ''et al.'' |title=Cutaneous digital papillary adenocarcinoma: a clinicopathologic study of 31 cases of a rare neoplasm with new observations |journal=Am. J. Surg. Pathol. |volume=36 |issue=12 |pages=1883–91 |year=2012 |month=December |pmid=23026931 |doi=10.1097/PAS.0b013e31826320ec |url=}}</ref> | |||
==General== | |||
*Very rare. | |||
*Aggressive - amputation is typically recommended.<ref>{{cite journal |author=Hsu HC, Ho CY, Chen CH, Yang CH, Hong HS, Chuang YH |title=Aggressive digital papillary adenocarcinoma: a review |journal=Clin. Exp. Dermatol. |volume=35 |issue=2 |pages=113–9 |year=2010 |month=March |pmid=19874325 |doi=10.1111/j.1365-2230.2009.03490.x |url=}}</ref> | |||
*Typically males 50-80 years old. | |||
**May be seen in adolescents.<ref>{{cite journal |author=Frey J, Shimek C, Woodmansee C, ''et al.'' |title=Aggressive digital papillary adenocarcinoma: a report of two diseases and review of the literature |journal=J. Am. Acad. Dermatol. |volume=60 |issue=2 |pages=331–9 |year=2009 |month=February |pmid=18819728 |doi=10.1016/j.jaad.2008.07.038 |url=}}</ref> | |||
==Gross== | |||
*Distal end of a finger or toe. | |||
**Usually fingers.<ref name=pmid23026931/> | |||
==Microscopic== | |||
Features: | |||
*Papillary projections - very common, not required. | |||
**Tubular structures. | |||
*Basaloid cells usually with mild-to-moderate atypia. | |||
*Fibrous stroma.<ref name=pmid24612571/> | |||
DDx: | |||
*[[Basal cell carcinoma]]. | |||
*[[Papillary eccrine adenoma]]. | |||
*Other basaloid tumours. | |||
===Images=== | |||
*[http://www.indianjcancer.com/viewimage.asp?img=IndianJournalofCancer_2011_48_1_126_76641_u2.jpg ADPA (indianjcancer.com)].<ref name=pmid21330762>{{cite journal |author=Rastrelli M, Soteldo J, Vitali GC, ''et al.'' |title=Aggressive digital papillary adenocarcinoma |journal=Indian J Cancer |volume=48 |issue=1 |pages=126–7 |year=2011 |pmid=21330762 |doi=10.4103/0019-509X.76641 |url=}}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3094519/figure/Fig3/ ADPA (nih.gov)].<ref>{{cite journal |author=Gole GN, Tati SY, Deshpande AK, Gole SG |title=Aggressive Digital Papillary Adenocarcinoma in a Young Female-a Rare Presentation |journal=J Hand Microsurg |volume=3 |issue=1 |pages=31–3 |year=2011 |month=June |pmid=22654416 |pmc=3094519 |doi=10.1007/s12593-010-0028-1 |url=}}</ref> | |||
*[http://escholarship.org/uc/item/212957kk.pdf ADPA (escholarship.org)].<ref name=pmid24612571>{{cite journal |author=Jefferson J, Thompson C, Rich P |title=A slowly enlarging mass on the finger |journal=Dermatol. Online J. |volume=20 |issue=2 |pages= |year=2014 |month=February |pmid=24612571 |doi= |url=}}</ref> | |||
==IHC== | |||
Features:<ref name=pmid23026931/> | |||
*Pankeratin +ve. | |||
*CEA +ve (edge of ducts/spaces). | |||
*EMA +ve (edge of ducts/spaces). | |||
*S-100 +ve (luminal cells). | |||
*SMA +ve (outer myoepithelial cell layer). | |||
*p63 +ve (outer myoepithelial cell layer). | |||
==See also== | ==See also== | ||
*[[Dermatopathology]]. | *[[Dermatopathology]]. | ||
==References== | |||
{{reflist|2}} | |||
[[Category:Dermatopathology]] | [[Category:Dermatopathology]] | ||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||