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Difference between revisions of "Diffuse lung diseases"
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→Usual interstitial pneumonia: re-arrange
(→Hypersensitivity pneumonitis: +ddx) |
(→Usual interstitial pneumonia: re-arrange) |
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*Disease of the old - rare in under 50 years old.<ref>AC UBC S.102.</ref> | *Disease of the old - rare in under 50 years old.<ref>AC UBC S.102.</ref> | ||
*Dismal prognosis - mean survival after diagnosis ~ 2.8 years.<ref name=pmid9445300>{{Cite journal | last1 = Bjoraker | first1 = JA. | last2 = Ryu | first2 = JH. | last3 = Edwin | first3 = MK. | last4 = Myers | first4 = JL. | last5 = Tazelaar | first5 = HD. | last6 = Schroeder | first6 = DR. | last7 = Offord | first7 = KP. | title = Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. | journal = Am J Respir Crit Care Med | volume = 157 | issue = 1 | pages = 199-203 | month = Jan | year = 1998 | doi = | PMID = 9445300 }}</ref> | *Dismal prognosis - mean survival after diagnosis ~ 2.8 years.<ref name=pmid9445300>{{Cite journal | last1 = Bjoraker | first1 = JA. | last2 = Ryu | first2 = JH. | last3 = Edwin | first3 = MK. | last4 = Myers | first4 = JL. | last5 = Tazelaar | first5 = HD. | last6 = Schroeder | first6 = DR. | last7 = Offord | first7 = KP. | title = Prognostic significance of histopathologic subsets in idiopathic pulmonary fibrosis. | journal = Am J Respir Crit Care Med | volume = 157 | issue = 1 | pages = 199-203 | month = Jan | year = 1998 | doi = | PMID = 9445300 }}</ref> | ||
===Radiology=== | ===Radiology=== | ||
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*Disease worse distant from large airways: lower lung field predominance, typically worse at periphery of lobule and lung.<ref>A. Churg. UBC S.103.</ref> | *Disease worse distant from large airways: lower lung field predominance, typically worse at periphery of lobule and lung.<ref>A. Churg. UBC S.103.</ref> | ||
*Heterogeneity of inflammation: airspace macrophages & inflammation minimal in honeycombed foci. | *Heterogeneity of inflammation: airspace macrophages & inflammation minimal in honeycombed foci. | ||
DDx of UIP is seen in:<ref name=leslie>{{cite book |author=Wick, Mark R.; Leslie, Kevin |title=Practical pulmonary pathology: a diagnostic approach |publisher=Churchill Livingstone |location=Edinburgh |year=2005 |pages= |isbn=0-443-06631-0 |oclc= 156861539|doi= |accessdate=}}</ref> | |||
*Idiopathic pulmonary fibrosis (UIP not otherwise specified). | |||
*Asbestosis - one ought to see ''ferruginous bodies''. | |||
*Chronic hypersensitivity pneumonitis (AKA extrinsic allergic alveolitis). | |||
*Collagen vascular disease - includes [[systemic lupus erythematosus]], [[rheumatoid arthritis]], [[scleroderma]].<ref>{{Ref PCPBoD8|374}}</ref> | |||
*Chronic drug toxicity.<ref>{{cite journal |author=Rossi SE, Erasmus JJ, McAdams HP, Sporn TA, Goodman PC |title=Pulmonary drug toxicity: radiologic and pathologic manifestations |journal=Radiographics : a review publication of the Radiological Society of North America, Inc |volume=20 |issue=5 |pages=1245-59 |year=2000 |pmid=10992015 |doi=}}</ref> | |||
==Asbestosis== | ==Asbestosis== | ||