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Difference between revisions of "Diffuse lung diseases"
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Diffuse lung diseases (view source)
Revision as of 23:04, 10 December 2011
, 23:04, 10 December 2011→Usual interstitial pneumonia: tweak
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*Abbreviated ''UIP''. | *Abbreviated ''UIP''. | ||
===General=== | ===General=== | ||
*It is sometimes used incorrectly as a | *It is sometimes used incorrectly as a synonym for ''idiopathic pulmonary fibrosis''. It is a histomorphologic pattern and has a DDx (see below). | ||
* | *UIP cannot be diagnosed via bronchoscopic or transbronchial biopsy,<ref name=Ref_PPP186>{{Ref PPP|186}}</ref> as it is peripheral. | ||
====Epidemiology==== | ====Epidemiology==== | ||
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**Usually subplural, i.e. peripheral lung. | **Usually subplural, i.e. peripheral lung. | ||
**Classically lower lobe predominant. | **Classically lower lobe predominant. | ||
* | *Traction bronchiectasis. | ||
Note: | Note: | ||
*Cysts - have thin walls (think of emphysema, lymphangioleiomyomatosis et cetera). | *Cysts - have thin walls (think of emphysema, [[lymphangioleiomyomatosis]] et cetera). | ||
**Cysts may be isolated/not close to a neighbour. | **Cysts may be isolated/not close to a neighbour. | ||
**Medcyclopaedia defines it as: thin-walled, well-demarcated and >1 cm.<ref>[http://www.medcyclopaedia.com/library/topics/volume_v_1/l/lung_cyst.aspx http://www.medcyclopaedia.com/library/topics/volume_v_1/l/lung_cyst.aspx]</ref> | **Medcyclopaedia defines it as: thin-walled, well-demarcated and >1 cm.<ref>[http://www.medcyclopaedia.com/library/topics/volume_v_1/l/lung_cyst.aspx http://www.medcyclopaedia.com/library/topics/volume_v_1/l/lung_cyst.aspx]</ref> | ||
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**Location: in the areas of transisition between active inflammation and old inflammation.<ref>[http://www.epler.com/IPFWhat%27sIPFDiseaseInformation2.htm http://www.epler.com/IPFWhat%27sIPFDiseaseInformation2.htm]</ref> | **Location: in the areas of transisition between active inflammation and old inflammation.<ref>[http://www.epler.com/IPFWhat%27sIPFDiseaseInformation2.htm http://www.epler.com/IPFWhat%27sIPFDiseaseInformation2.htm]</ref> | ||
**Note: Technically, ''fibroblast foci'' are composed of myofibroblasts.<ref name=Ref_PPP189>{{Ref PPP|189}}</ref> | **Note: Technically, ''fibroblast foci'' are composed of myofibroblasts.<ref name=Ref_PPP189>{{Ref PPP|189}}</ref> | ||
*Interstitial inflammation | *Interstitial inflammation. | ||
*Microscopic honeycombing | *Microscopic honeycombing. | ||
**Typically peripheral - cysts lined by ciliated epithelium. | **Typically peripheral - cysts lined by ciliated epithelium. | ||
*Spatial heterogeneity - patchy lesional distribution (areas of abnormal and normal lung may appear beside one another). | *Spatial heterogeneity - patchy lesional distribution (areas of abnormal and normal lung may appear beside one another). | ||
*Temporal heterogeneity - lesions of differing age side-by-side.<ref> | *Temporal heterogeneity - lesions of differing age side-by-side.<ref name=Ref_WMSP92>{{Ref WMSP|92}}</ref> | ||
Notes: | Notes: | ||