DNA repair genes

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DNA repair genes fix broken DNA. Failure of DNA repair can lead to cancer.

There is a long and growing list of DNA repair genes.[1]

Examples

Gene Syndrome Tumours
BRCA1 familial breast and ovarian cancer breast, ovary, prostate, pancreas, male breast, fallopian tube
BRCA2 familial breast and ovarian cancer 2 breast, ovary, prostate, pancreas, stomach, male breast, melanoma, stomach, biliary, pharynx
MSH2 Lynch syndrome colorectal, endometrial, gastric, pancreas, urothelial, biliary

References

  1. Wood, RD.; Mitchell, M.; Sgouros, J.; Lindahl, T. (Feb 2001). "Human DNA repair genes.". Science 291 (5507): 1284-9. doi:10.1126/science.1056154. PMID 11181991.