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Difference between revisions of "Cystitis cystica"
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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Cystitis_cystica_-_alt_--_intermed_mag.jpg | |||
| Width = | |||
| Caption = Cystitis cystica. [[H&E stain]]. | |||
| Synonyms = | |||
| Micro = nests of urothelium within the lamina propria with cyst formation, i.e. lumens are present; no nuclear atypia | |||
| Subtypes = | |||
| LMDDx = [[nested urothelial carcinoma]], [[cystitis cystica et glandularis]], [[inverted urothelial papilloma]] | |||
| Stains = | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[urinary bladder]] - see ''[[urothelium]]'' | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = | |||
| Symptoms = | |||
| Prevalence = common | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = benign | |||
| Other = | |||
| ClinDDx = [[urothelial carcinoma]] | |||
| Tx = | |||
}} | |||
'''Cystitis cystica''' is a common inflammatory process of the [[urinary bladder]] with cyst formation. | |||
==General== | |||
*Benign. | |||
*Can be thought of as [[von Brunn nests]] with cystic change.<ref name=Ref_WMSP304>{{Ref WMSP|304}}</ref> | |||
*Called ''[[ureteritis cystica]]'' if it happens in a [[ureter]].<ref name=pmid21966620 >{{Cite journal | last1 = Rothschild | first1 = JG. | last2 = Wu | first2 = G. | title = Ureteritis cystica: a radiologic pathologic correlation. | journal = J Clin Imaging Sci | volume = 1 | issue = | pages = 23 | month = | year = 2011 | doi = 10.4103/2156-7514.80375 | PMID = 21966620 }}</ref> | |||
**There is also a ''urethritis cystica'' - seen in the [[urethra]].<ref name=pmid22397870>{{Cite journal | last1 = Conces | first1 = MR. | last2 = Williamson | first2 = SR. | last3 = Montironi | first3 = R. | last4 = Lopez-Beltran | first4 = A. | last5 = Scarpelli | first5 = M. | last6 = Cheng | first6 = L. | title = Urethral caruncle: clinicopathologic features of 41 cases. | journal = Hum Pathol | volume = 43 | issue = 9 | pages = 1400-4 | month = Sep | year = 2012 | doi = 10.1016/j.humpath.2011.10.015 | PMID = 22397870 }}</ref> | |||
==Microscopic== | |||
Features:<ref name=Ref_PBoD1028>{{Ref PBoD|1028}}</ref> | |||
*Nests of urothelium within the lamina propria with cyst formation, i.e. lumens are present. | |||
Note: | |||
*Nests should '''not''' extend into the muscularis propria. | |||
DDx: | |||
*[[Nested urothelial carcinoma]].<ref name=pmid19800100>{{Cite journal | last1 = Wasco | first1 = MJ. | last2 = Daignault | first2 = S. | last3 = Bradley | first3 = D. | last4 = Shah | first4 = RB. | title = Nested variant of urothelial carcinoma: a clinicopathologic and immunohistochemical study of 30 pure and mixed cases. | journal = Hum Pathol | volume = 41 | issue = 2 | pages = 163-71 | month = Feb | year = 2010 | doi = 10.1016/j.humpath.2009.07.015 | PMID = 19800100 }} | |||
</ref> | |||
*[[Cystitis cystica et glandularis]] - has goblet cells. | |||
*[[Inverted urothelial papilloma]] - peripheral palisading, higher architectural complexity. | |||
===Images=== | |||
<gallery> | |||
Image: Cystitis cystica -- low mag.jpg | CC - low mag. | |||
Image: Cystitis cystica -- intermed mag.jpg | CC - intermed. mag. | |||
Image: Cystitis cystica - rot -- intermed mag.jpg | CC - intermed. mag. | |||
Image: Cystitis cystica -- high mag.jpg | CC - high mag. | |||
Image: Cystitis cystica - alt -- intermed mag.jpg | CC - intermed. mag. | |||
Image: Cystitis cystica - alt -- high mag.jpg | CC - high mag. | |||
</gallery> | |||
www: | |||
*[http://www.webpathology.com/image.asp?n=1&Case=50 Cystitis cystica (webpathology.com)]. | |||
==Sign out== | |||
<pre> | |||
URINARY BLADDER, BIOPSY: | |||
- CYSTITIS CYSTICA. | |||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
<pre> | |||
URINARY BLADDER, TRANSURETHRAL RESECTION: | |||
- CYSTITIS CYSTICA ET GLANDULARIS, FOCALLY WITH LARGE THIN-WALLED CYSTS. | |||
- PROMINENT BENIGN DILATED SUPERFICIAL BLOOD VESSELS, FOCAL. | |||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
<pre> | |||
URINARY BLADDER (TRIGONE), TRANSURETHRAL BIOPSY: | |||
- SMALL POLYPOID FRAGMENT OF UROTHELIUM CONSISTENT WITH CYSTITIS CYSTICA. | |||
- NO SQUAMOUS METAPLASTIC CHANGE IDENTIFIED. | |||
- NO EVIDENCE OF MALIGNANCY. | |||
</pre> | |||
===Micro=== | |||
The sections show a small fragment of urothelial mucosa with small urothelial nests that are focally cystic. The nests are well-circumscribed and approximately of equal size. Adjacent to the nests is a small cluster of bland appearing lymphocytes. | |||
No exophytic component is identified. No papillary structures are apparent. The cytomorphology of the urothelium is bland and no mitotic activity is readily apparent. | |||
==See also== | |||
*[[Urothelium]]. | |||
*[[Cystitis glandularis]]. | |||
==References== | |||
{{Reflist|2}} | |||
[[Category:Diagnosis]] | [[Category:Diagnosis]] | ||
[[Category:Urothelium]] | |||