Difference between revisions of "Cushing syndrome"

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'''Cushing syndrome''', also '''hypercortisolism''', is when there is too much glucocorticoids.
'''Cushing syndrome''', also '''hypercortisolism''', is when there is too much glucocorticoids.
==Clinical==
The features can be remembered with ''CUSHING'':<ref>URL: [http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html]. Accessed on: 1 May 2012.</ref>
*'''C'''entral obesity + '''C'''ervical fat pad + '''C'''omedones (acne).
*'''U'''nusual brUising.
*'''S'''triae.
*'''H'''ypertension + '''H'''yperglycemia.
*'''I'''mmunosuppression.
*'''N'''eoplasia may cause it.
*'''G'''rowth retardation.
A shorter version is ''CUSH'':
*'''C'''entral obesity with peripheral wasting, '''C'''ervical fat pad.
*'''U'''nusual br'''U'''ising.
*'''S'''traiae on Skin.
*'''H'''ypertension + '''H'''yperglycemia.


==Microscopic==
==Microscopic==
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*Crooke-hyaline change:<ref>{{Ref PCPBoD8|581}}</ref>
*Crooke-hyaline change:<ref>{{Ref PCPBoD8|581}}</ref>
**ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous.
**ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous.
<gallery>
File:Crooke HE 40x.jpg | Crooke´s cell adenoma showing various Crooke cells with hyalinzed cytoplasms. (WC/marvin101)
File:Crooke Cytokeratins.jpg | Ringlike perinuclear expression of cytokeratins in Crooke´s cell adenoma. (WC/marvin101)
</gallery>


==See also==
==See also==
*[[Avascular necrosis of the femoral head]].
*[[Avascular necrosis of the femoral head]].
*[[Cushing disease]].


==References==
==References==

Latest revision as of 12:30, 16 June 2015

Cushing syndrome, also hypercortisolism, is when there is too much glucocorticoids.

Clinical

The features can be remembered with CUSHING:[1]

  • Central obesity + Cervical fat pad + Comedones (acne).
  • Unusual brUising.
  • Striae.
  • Hypertension + Hyperglycemia.
  • Immunosuppression.
  • Neoplasia may cause it.
  • Growth retardation.

A shorter version is CUSH:

  • Central obesity with peripheral wasting, Cervical fat pad.
  • Unusual brUising.
  • Straiae on Skin.
  • Hypertension + Hyperglycemia.

Microscopic

Features - pituitary gland:

  • Crooke-hyaline change:[2]
    • ACTH producing cell: basophilic granular cytoplasm becomes pale and homogenous.

See also

References

  1. URL: http://www.usmletomd.com/smartmd/2007/09/remembering-clinical-features-of.html. Accessed on: 1 May 2012.
  2. Mitchell, Richard; Kumar, Vinay; Fausto, Nelson; Abbas, Abul K.; Aster, Jon (2011). Pocket Companion to Robbins & Cotran Pathologic Basis of Disease (8th ed.). Elsevier Saunders. pp. 581. ISBN 978-1416054542.