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Difference between revisions of "Crizotinib"
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'''Crizotinib''' a drug used to treat lung cancer. Its' trade name is ''Xalkori'' (Pfizer).<ref>URL: [https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/crizotinib https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/crizotinib]. Accessed on: November 8, 2018.</ref> It is an [[ALK inhibitor]]. | '''Crizotinib''' a drug used to treat lung cancer. Its' trade name is ''Xalkori'' (Pfizer).<ref>URL: [https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/crizotinib https://www.cancerresearchuk.org/about-cancer/cancer-in-general/treatment/cancer-drugs/drugs/crizotinib]. Accessed on: November 8, 2018.</ref> It is an [[ALK inhibitor]]. | ||
*Lung cancer with ROS1 rearrangement.<ref name=pmid25264305>{{Cite journal | last1 = Shaw | first1 = AT. | last2 = Ou | first2 = SH. | last3 = Bang | first3 = YJ. | last4 = Camidge | first4 = DR. | last5 = Solomon | first5 = BJ. | last6 = Salgia | first6 = R. | last7 = Riely | first7 = GJ. | last8 = Varella-Garcia | first8 = M. | last9 = Shapiro | first9 = GI. | title = Crizotinib in ROS1-rearranged non-small-cell lung cancer. | journal = N Engl J Med | volume = 371 | issue = 21 | pages = 1963-71 | month = Nov | year = 2014 | doi = 10.1056/NEJMoa1406766 | PMID = 25264305 }}</ref> | *[[Lung cancer with ROS1 rearrangement]].<ref name=pmid25264305>{{Cite journal | last1 = Shaw | first1 = AT. | last2 = Ou | first2 = SH. | last3 = Bang | first3 = YJ. | last4 = Camidge | first4 = DR. | last5 = Solomon | first5 = BJ. | last6 = Salgia | first6 = R. | last7 = Riely | first7 = GJ. | last8 = Varella-Garcia | first8 = M. | last9 = Shapiro | first9 = GI. | title = Crizotinib in ROS1-rearranged non-small-cell lung cancer. | journal = N Engl J Med | volume = 371 | issue = 21 | pages = 1963-71 | month = Nov | year = 2014 | doi = 10.1056/NEJMoa1406766 | PMID = 25264305 }}</ref> | ||
*[[Lung carcinoma with ALK rearrangement]].<ref>{{Cite journal | last1 = Wu | first1 = YL. | last2 = Lu | first2 = S. | last3 = Lu | first3 = Y. | last4 = Zhou | first4 = J. | last5 = Shi | first5 = YK. | last6 = Sriuranpong | first6 = V. | last7 = Ho | first7 = JCM. | last8 = Ong | first8 = CK. | last9 = Tsai | first9 = CM. | title = Results of PROFILE 1029, a Phase III Comparison of First-Line Crizotinib versus Chemotherapy in East Asian Patients with ALK-Positive Advanced Non-Small Cell Lung Cancer. | journal = J Thorac Oncol | volume = | issue = | pages = | month = Jun | year = 2018 | doi = 10.1016/j.jtho.2018.06.012 | PMID = 29966800 }}</ref> | *[[Lung carcinoma with ALK rearrangement]].<ref>{{Cite journal | last1 = Wu | first1 = YL. | last2 = Lu | first2 = S. | last3 = Lu | first3 = Y. | last4 = Zhou | first4 = J. | last5 = Shi | first5 = YK. | last6 = Sriuranpong | first6 = V. | last7 = Ho | first7 = JCM. | last8 = Ong | first8 = CK. | last9 = Tsai | first9 = CM. | title = Results of PROFILE 1029, a Phase III Comparison of First-Line Crizotinib versus Chemotherapy in East Asian Patients with ALK-Positive Advanced Non-Small Cell Lung Cancer. | journal = J Thorac Oncol | volume = | issue = | pages = | month = Jun | year = 2018 | doi = 10.1016/j.jtho.2018.06.012 | PMID = 29966800 }}</ref> | ||
*Lung carcinoma with MET amplification.<ref>{{Cite journal | last1 = Forde | first1 = PM. | last2 = Rudin | first2 = CM. | title = Crizotinib in the treatment of non-small-cell lung cancer. | journal = Expert Opin Pharmacother | volume = 13 | issue = 8 | pages = 1195-201 | month = Jun | year = 2012 | doi = 10.1517/14656566.2012.688029 | PMID = 22594847 }}</ref> | *Lung carcinoma with MET amplification.<ref>{{Cite journal | last1 = Forde | first1 = PM. | last2 = Rudin | first2 = CM. | title = Crizotinib in the treatment of non-small-cell lung cancer. | journal = Expert Opin Pharmacother | volume = 13 | issue = 8 | pages = 1195-201 | month = Jun | year = 2012 | doi = 10.1517/14656566.2012.688029 | PMID = 22594847 }}</ref> | ||