Difference between revisions of "Course:Introduction to Neuropathology"
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Jensflorian (talk | contribs) (→Typical staining patterns: case 3) |
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====Typical staining patterns==== | ====Typical staining patterns==== | ||
*Glioblastoma | |||
<gallery> | <gallery> | ||
File:Neuropathology_case_IX_02.jpg | [[H&E]] | File:Neuropathology_case_IX_02.jpg | [[H&E]] | ||
File:Neuropathology_case_IX_04.jpg | [[GFAP]] | File:Neuropathology_case_IX_04.jpg | [[GFAP]] | ||
File:Neuropathology_case_IX_06.jpg | MIB-1 | File:Neuropathology_case_IX_06.jpg | MIB-1 | ||
File: | File:Neuroparthology case IX 0125.jpg | [[ATRX]] | ||
File: | File:Neuropathology case IX.jpg | [[IDH1]] | ||
File: | File:Neuropathology case IX.jpg | panCK | ||
</gallery> | </gallery> | ||
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}} | }} | ||
*Oligodendroglioma | |||
<gallery> | <gallery> | ||
File:Oligodendroglioma1 low mag.jpg | [[H&E]] | File:Oligodendroglioma1 low mag.jpg | [[H&E]] | ||
File: | File:Oligodendorglioma GFAP.jpg| [[GFAP]] | ||
File:Neuropathology case II 04.jpg | MIB-1 | File:Neuropathology case II 04.jpg | MIB-1 | ||
File:Neuroparthology case IX 0125.jpg | ATRX | File:Neuroparthology case IX 0125.jpg | [[ATRX]] | ||
File:IDH1 R132H in anaplastic ologodendroglioma.jpg | [[IDH1]] | File:IDH1 R132H in anaplastic ologodendroglioma.jpg | [[IDH1]] | ||
File:Neuropathology case IX.jpg | panCK | File:Neuropathology case IX.jpg | panCK | ||
</gallery> | </gallery> | ||
[[Oligodendroglioma]] is a diffuse geowing glial tumour with clear cell morphology. In WHO grade II the MIB-1 proliferation index is rather low. GFAP stains the neuropil background and minigemistocytes (if present). There is no ATRX loss. The vast majority of oligodendrogliomas stain positively for IDH1 R132H mutation. | [[Oligodendroglioma]] is a diffuse geowing glial tumour with clear cell morphology. In WHO grade II the MIB-1 proliferation index is rather low. GFAP stains the neuropil background and minigemistocytes (if present). There is no ATRX loss. The vast majority of oligodendrogliomas stain positively for IDH1 R132H mutation.There is no expression of epithelial markers (panCK). | ||
{{hidden|Other language: German|Oligodendrogliome sind diffus wachsende gliale Tumore mit klarzelligem Aspekt in der Morphologie. In WHO Grad II Tumoren ist der MIB-1 Proliferationsindex gering. GFAP färbt vor allem das Neuropil im Hintergrund sowie Minigemistozyten, wenn diese im Tumor vorkommen. Es findet sich kein ATRX Verlust. Der Großteil der Oligodendrogliome ist positiv für die IDH1 R132H Mutation. Epitheliale Marker wie panCK werden nicht exprimiert}} | |||
*Astrocytoma | |||
<gallery> | |||
File:Astrocytoma whoII HE.jpg | |||
File:GFAP astrocytoma.jpg | [[GFAP]] | |||
File:Neuropathology case II 04.jpg | MIB-1 | |||
File:Neuropathology case II ATRX immunohistochemistry.jpg | [[ATRX]] | |||
File:IDH1R132H oligoastrocytoma.jpg | | [[IDH1]] | |||
File:Neuropathology case IX.jpg | panCK | |||
</gallery> | |||
[Astrocytoma]] is a diffusely growing tumor with low cell density, neoplastic astrocytes resting in a fibrillary backrgound and low MIB1 index. GFAP is strong and also stains the cell processes. IND1 R132H postive astrocytomas usually exhibit nuclear ATRX loss. There is no expression of epithelial markers (panCK). | |||
{{hidden|Other language: German|Astrozytome sind diffus wachsende gliale Tumore mit sternförmigen Astrozyten auf einem fibrillärem Untergrund. In WHO Grad II Tumoren ist der MIB-1 Proliferationsindex gering. GFAP färbt die Tumorzellen und den Hintergrund stark an Es findet sich in IDH1 R132H mutierten Tumoren häufig ein ATRX Verlust. Epitheliale Marker wie panCK werden nicht exprimiert}} | |||
A descriptive overview of various brain tumours is found [[Neuropathology tumours|here]]. | A descriptive overview of various brain tumours is found [[Neuropathology tumours|here]]. | ||