Difference between revisions of "Complex sclerosing lesion"
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*May appear malignant on imaging.<ref name=pmid11167596>{{cite journal |author=Ung OA, Lee WB, Greenberg ML, Bilous M |title=Complex sclerosing lesion: the lesion is complex, the management is straightforward |journal=ANZ J Surg |volume=71 |issue=1 |pages=35–40 |year=2001 |month=January |pmid=11167596 |doi= |url=}}</ref> | *May appear malignant on imaging.<ref name=pmid11167596>{{cite journal |author=Ung OA, Lee WB, Greenberg ML, Bilous M |title=Complex sclerosing lesion: the lesion is complex, the management is straightforward |journal=ANZ J Surg |volume=71 |issue=1 |pages=35–40 |year=2001 |month=January |pmid=11167596 |doi= |url=}}</ref> | ||
*Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref> | *Associated with subsequent elevated risk of breast cancer.<ref>URL: [http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp]. Accessed on: 4 May 2010.</ref> | ||
**Typically [[BI-RADS]] 4 - but may be BI-RADS 5.<ref name=pmid24936496>{{Cite journal | last1 = Myong | first1 = JH. | last2 = Choi | first2 = BG. | last3 = Kim | first3 = SH. | last4 = Kang | first4 = BJ. | last5 = Lee | first5 = A. | last6 = Song | first6 = BJ. | title = Imaging features of complex sclerosing lesions of the breast. | journal = Ultrasonography | volume = 33 | issue = 1 | pages = 58-64 | month = Jan | year = 2014 | doi = 10.14366/usg.13015 | PMID = 24936496 }}</ref> | |||
*Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal |author=Kennedy M, Masterson AV, Kerin M, Flanagan F |title=Pathology and clinical relevance of radial scars: a review |journal=J. Clin. Pathol. |volume=56 |issue=10 |pages=721–4 |year=2003 |month=October |pmid=14514771 |pmc=1770086 |doi= |url=}}</ref> | *Management - usu. surgical excision.<ref name=pmid14514771>{{cite journal |author=Kennedy M, Masterson AV, Kerin M, Flanagan F |title=Pathology and clinical relevance of radial scars: a review |journal=J. Clin. Pathol. |volume=56 |issue=10 |pages=721–4 |year=2003 |month=October |pmid=14514771 |pmc=1770086 |doi= |url=}}</ref> | ||
==Gross== | ==Gross== | ||
Revision as of 18:12, 1 January 2017
| Complex sclerosing lesion | |
|---|---|
| Diagnosis in short | |
 Complex sclerosing lesion of breast. H&E stain. (WC) | |
|
| |
| Synonyms | radial scar |
|
| |
| LM | stellate lesion (low magnification), center of lesion has fibroelastosis (stroma light pink on H&E), scar like stroma with entrapped normal breast ducts and lobules - glands appear to enlarge with distance from center of lesion |
| LM DDx | invasive ductal carcinoma |
| IHC | myoepithelial cells preset (p63 +ve, calponin +ve) |
| Gross | spiculated mass |
| Site | breast |
|
| |
| Prognosis | benign, increased risk of malignancy |
| Clin. DDx | breast cancer |
| Treatment | excision |
Complex sclerosing lesion (abbreviated CSL), also radial scar, is a benign lesion of the breast that is associated with an increased risk of subsequent breast cancer.
General
- The term radial scar is a misnomer. It isn't a scar. It isn't associated with prior trauma or surgery.[1]
- May appear malignant on imaging.[2]
- Associated with subsequent elevated risk of breast cancer.[3]
- Management - usu. surgical excision.[5]
Gross
- Spiculated mass.
- Usually small - 3-7 mm.
Image
Radial scar - gross. (WC)
Microscopic
- Stellate appearance (low magnification).
- Center of lesion has "fibroelastosis" - stroma light pink (on H&E) - key feature.
- Scar like stroma with entrapped normal breast ducts and lobules.
- Glands appear to enlarge with distance from center of lesion.
Notes:
- Histomorphologic appearance may mimic a desmoplastic reaction of the stroma - leading to a misdiagnosis of malignancy.
- "Hyaline - pink stuff on H&E - is the key."
DDx:
- Invasive ductal carcinoma - should be considered if the lesion is asymmetrical or glands are dilated centrally.
Images
RS - low mag. (WC)
RS - intermed. mag. (WC)
www
IHC
Features:
- p63 +ve.
- Calponin +ve.
Note:
- HMWK +ve/-ve. (???)
See also
References
- ↑ Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon (2009). Robbins and Cotran pathologic basis of disease (8th ed.). Elsevier Saunders. pp. 1072. ISBN 978-1416031215.
- ↑ Ung OA, Lee WB, Greenberg ML, Bilous M (January 2001). "Complex sclerosing lesion: the lesion is complex, the management is straightforward". ANZ J Surg 71 (1): 35–40. PMID 11167596.
- ↑ URL: http://www.cancer.org/docroot/NWS/content/NWS_1_1x_Radial_Scars.asp. Accessed on: 4 May 2010.
- ↑ Myong, JH.; Choi, BG.; Kim, SH.; Kang, BJ.; Lee, A.; Song, BJ. (Jan 2014). "Imaging features of complex sclerosing lesions of the breast.". Ultrasonography 33 (1): 58-64. doi:10.14366/usg.13015. PMID 24936496.
- ↑ 5.0 5.1 Kennedy M, Masterson AV, Kerin M, Flanagan F (October 2003). "Pathology and clinical relevance of radial scars: a review". J. Clin. Pathol. 56 (10): 721–4. PMC 1770086. PMID 14514771. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1770086/.
- ↑ O'Malley, Frances P.; Pinder, Sarah E. (2006). Breast Pathology: A Volume in Foundations in Diagnostic Pathology series (1st ed.). Churchill Livingstone. pp. 91. ISBN 978-0443066801.