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Difference between revisions of "Common variable immunodeficiency"
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Common variable immunodeficiency (view source)
Revision as of 22:13, 24 March 2016
, 22:13, 24 March 2016→General
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Features:<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref> | Features:<ref name=pmid20629103>{{cite journal |author=Agarwal S, Smereka P, Harpaz N, Cunningham-Rundles C, Mayer L |title=Characterization of immunologic defects in patients with common variable immunodeficiency (CVID) with intestinal disease |journal=Inflamm Bowel Dis |volume= |issue= |pages= |year=2010 |month=July |pmid=20629103 |doi=10.1002/ibd.21376 |url=}}</ref> | ||
*Recurrent sinus and pulmonary infections. | *Recurrent sinus and pulmonary infections. | ||
**Pneumonia seen in ~1/3 of ~2200 patients.<ref name=pmid24582312>{{Cite journal | last1 = Gathmann | first1 = B. | last2 = Mahlaoui | first2 = N. | last3 = Gérard | first3 = L. | last4 = Oksenhendler | first4 = E. | last5 = Warnatz | first5 = K. | last6 = Schulze | first6 = I. | last7 = Kindle | first7 = G. | last8 = Kuijpers | first8 = TW. | last9 = van Beem | first9 = RT. | title = Clinical picture and treatment of 2212 patients with common variable immunodeficiency. | journal = J Allergy Clin Immunol | volume = 134 | issue = 1 | pages = 116-26 | month = Jul | year = 2014 | doi = 10.1016/j.jaci.2013.12.1077 | PMID = 24582312 }}</ref> | |||
*[[Splenomegaly]] - seen in ~ 25% of ~2200 patients.<ref name=pmid24582312/> | |||
*[[Inflammatory bowel disease]]-like disease. | *[[Inflammatory bowel disease]]-like disease. | ||
*Often diagnosed in adulthood ~ mean age 43+/-14 years.<ref name=pmid26992251/> | *Often diagnosed in adulthood ~ mean age 43+/-14 years.<ref name=pmid26992251/> | ||
Labs in a series of 8 patients:<ref name=pmid26992251>{{Cite journal | last1 = Dong | first1 = J. | last2 = Liang | first2 = H. | last3 = Wen | first3 = D. | last4 = Wang | first4 = J. | title = Adult Common Variable Immunodeficiency. | journal = Am J Med Sci | volume = 351 | issue = 3 | pages = 239-43 | month = Mar | year = 2016 | doi = 10.1016/j.amjms.2015.12.010 | PMID = 26992251 }}</ref> | Labs in a series of 8 patients:<ref name=pmid26992251>{{Cite journal | last1 = Dong | first1 = J. | last2 = Liang | first2 = H. | last3 = Wen | first3 = D. | last4 = Wang | first4 = J. | title = Adult Common Variable Immunodeficiency. | journal = Am J Med Sci | volume = 351 | issue = 3 | pages = 239-43 | month = Mar | year = 2016 | doi = 10.1016/j.amjms.2015.12.010 | PMID = 26992251 }}</ref> | ||