Difference between revisions of "Collagenous sprue"

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| Subtypes  =
| Subtypes  =
| LMDDx      = [[celiac disease]]
| LMDDx      = [[celiac disease]]
| Stains    = demonstrate collagen - [[Masson trichrome]], [[Mallory trichrome]]
| Stains    = demonstrate collagen - [[Masson trichrome stain|Masson trichrome]], [[Mallory trichrome stain|Mallory trichrome]]
| IHC        =
| IHC        =
| EM        =
| EM        =
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*[http://www.nature.com/modpathol/journal/v23/n1/fig_tab/modpathol2009151f2.html Collagenous sprue - several images (nature.com)].<ref name=pmid19855376>{{Cite journal  | last1 = Vakiani | first1 = E. | last2 = Arguelles-Grande | first2 = C. | last3 = Mansukhani | first3 = MM. | last4 = Lewis | first4 = SK. | last5 = Rotterdam | first5 = H. | last6 = Green | first6 = PH. | last7 = Bhagat | first7 = G. | title = Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. | journal = Mod Pathol | volume = 23 | issue = 1 | pages = 12-26 | month = Jan | year = 2010 | doi = 10.1038/modpathol.2009.151 | PMID = 19855376 }}</ref>
*[http://www.nature.com/modpathol/journal/v23/n1/fig_tab/modpathol2009151f2.html Collagenous sprue - several images (nature.com)].<ref name=pmid19855376>{{Cite journal  | last1 = Vakiani | first1 = E. | last2 = Arguelles-Grande | first2 = C. | last3 = Mansukhani | first3 = MM. | last4 = Lewis | first4 = SK. | last5 = Rotterdam | first5 = H. | last6 = Green | first6 = PH. | last7 = Bhagat | first7 = G. | title = Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. | journal = Mod Pathol | volume = 23 | issue = 1 | pages = 12-26 | month = Jan | year = 2010 | doi = 10.1038/modpathol.2009.151 | PMID = 19855376 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886398/figure/F2/ Collagenous sprue (nih.gov)].<ref name=pmid20574500>{{Cite journal  | last1 = Xiao | first1 = Z. | last2 = Dasari | first2 = VM. | last3 = Kirby | first3 = DF. | last4 = Bronner | first4 = M. | last5 = Plesec | first5 = TP. | last6 = Lashner | first6 = BA. | title = Collagenous sprue: a case report and literature review. | journal = Gastroenterol Hepatol (N Y) | volume = 5 | issue = 6 | pages = 418-24 | month = Jun | year = 2009 | doi =  | PMID = 20574500 }}</ref>
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886398/figure/F2/ Collagenous sprue (nih.gov)].<ref name=pmid20574500>{{Cite journal  | last1 = Xiao | first1 = Z. | last2 = Dasari | first2 = VM. | last3 = Kirby | first3 = DF. | last4 = Bronner | first4 = M. | last5 = Plesec | first5 = TP. | last6 = Lashner | first6 = BA. | title = Collagenous sprue: a case report and literature review. | journal = Gastroenterol Hepatol (N Y) | volume = 5 | issue = 6 | pages = 418-24 | month = Jun | year = 2009 | doi =  | PMID = 20574500 }}</ref>
==Stains==
Stains to demonstrate collagen:
*[[Mallory trichrome stain|Mallory trichrome]].
*[[Masson trichrome stain|Masson trichrome]].


==See also==
==See also==

Revision as of 13:42, 26 December 2013

Collagenous sprue
Diagnosis in short

LM subepithelial collagen layer > 12 micrometres, villous atrophy, crypt atrophy.
LM DDx celiac disease
Stains demonstrate collagen - Masson trichrome, Mallory trichrome
Site small bowel

Associated Dx possibly celiac disease
Clinical history unresponsive to gluten free diet
Prevalence very rare

Collagenous sprue is a very rare disorder of the small bowel. There are approximately 60 reported cases in the world literature.[1]

General

Clinical:

  • Diarrhea.
    • Not responsive to Gluten-free diet.

Microscopic

Features:[1]

  • Subepithelial collagen layer > 12 micrometres - key feature.
  • Villous atrophy.
  • Crypt atrophy.

DDx:

Images

Stains

Stains to demonstrate collagen:

See also

References

  1. 1.0 1.1 1.2 Zhao, X.; Johnson, RL. (Jun 2011). "Collagenous sprue: a rare, severe small-bowel malabsorptive disorder.". Arch Pathol Lab Med 135 (6): 803-9. doi:10.1043/2010-0028-RS.1. PMID 21631278.
  2. Busto-Bea, V.; Crespo-Pérez, L.; García-Miralles, N.; Ruiz-Del-Árbol-Olmos, L.; Cano-Ruiz, A. (May 2013). "Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation.". Rev Esp Enferm Dig 105 (3): 171-174. PMID 23735026.
  3. Vakiani, E.; Arguelles-Grande, C.; Mansukhani, MM.; Lewis, SK.; Rotterdam, H.; Green, PH.; Bhagat, G. (Jan 2010). "Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients.". Mod Pathol 23 (1): 12-26. doi:10.1038/modpathol.2009.151. PMID 19855376.
  4. Xiao, Z.; Dasari, VM.; Kirby, DF.; Bronner, M.; Plesec, TP.; Lashner, BA. (Jun 2009). "Collagenous sprue: a case report and literature review.". Gastroenterol Hepatol (N Y) 5 (6): 418-24. PMID 20574500.