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Difference between revisions of "Collagenous sprue"
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'''Collagenous sprue''' is a very rare disorder of the [[small bowel]] | {{ Infobox diagnosis | ||
| Name = {{PAGENAME}} | |||
| Image = | |||
| Width = | |||
| Caption = | |||
| Synonyms = | |||
| Micro = subepithelial collagen layer > 12 micrometres, villous atrophy, crypt atrophy | |||
| Subtypes = | |||
| LMDDx = [[celiac disease]] | |||
| Stains = demonstrate collagen - [[Masson trichrome stain|Masson trichrome]], [[Mallory trichrome stain|Mallory trichrome]] | |||
| IHC = | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[small bowel]] | |||
| Assdx = possibly [[celiac disease]] | |||
| Syndromes = | |||
| Clinicalhx = unresponsive to gluten free diet | |||
| Signs = diarrhea | |||
| Symptoms = | |||
| Prevalence = very rare | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = | |||
| Tx = | |||
}} | |||
'''Collagenous sprue''' is a very rare disorder of the [[small bowel]]. There are approximately 60 reported cases in the world literature.<ref name=pmid21631278 >{{Cite journal | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref> | |||
==General== | ==General== | ||
*Thought to be related to [[celiac sprue]] - though somewhat controversial.<ref name=pmid21631278>{{Cite journal | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref><ref name=pmid23735026>{{Cite journal | last1 = Busto-Bea | first1 = V. | last2 = Crespo-Pérez | first2 = L. | last3 = García-Miralles | first3 = N. | last4 = Ruiz-Del-Árbol-Olmos | first4 = L. | last5 = Cano-Ruiz | first5 = A. | title = Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation. | journal = Rev Esp Enferm Dig | volume = 105 | issue = 3 | pages = 171-174 | month = May | year = 2013 | doi = | PMID = 23735026 }}</ref> | *Thought to be related to [[celiac sprue]] - though somewhat controversial.<ref name=pmid21631278>{{Cite journal | last1 = Zhao | first1 = X. | last2 = Johnson | first2 = RL. | title = Collagenous sprue: a rare, severe small-bowel malabsorptive disorder. | journal = Arch Pathol Lab Med | volume = 135 | issue = 6 | pages = 803-9 | month = Jun | year = 2011 | doi = 10.1043/2010-0028-RS.1 | PMID = 21631278 }}</ref><ref name=pmid23735026>{{Cite journal | last1 = Busto-Bea | first1 = V. | last2 = Crespo-Pérez | first2 = L. | last3 = García-Miralles | first3 = N. | last4 = Ruiz-Del-Árbol-Olmos | first4 = L. | last5 = Cano-Ruiz | first5 = A. | title = Collagenous sprue: Don´t forget connective tissue in chronic diarrhea evaluation. | journal = Rev Esp Enferm Dig | volume = 105 | issue = 3 | pages = 171-174 | month = May | year = 2013 | doi = | PMID = 23735026 }}</ref> | ||
Clinical: | |||
*Diarrhea. | |||
**Not responsive to Gluten-free diet. | |||
==Microscopic== | ==Microscopic== | ||
| Line 12: | Line 47: | ||
DDx: | DDx: | ||
*[[Celiac sprue]]. | *[[Celiac sprue]]. | ||
===Images=== | |||
*[http://www.nature.com/modpathol/journal/v23/n1/fig_tab/modpathol2009151f2.html Collagenous sprue - several images (nature.com)].<ref name=pmid19855376>{{Cite journal | last1 = Vakiani | first1 = E. | last2 = Arguelles-Grande | first2 = C. | last3 = Mansukhani | first3 = MM. | last4 = Lewis | first4 = SK. | last5 = Rotterdam | first5 = H. | last6 = Green | first6 = PH. | last7 = Bhagat | first7 = G. | title = Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. | journal = Mod Pathol | volume = 23 | issue = 1 | pages = 12-26 | month = Jan | year = 2010 | doi = 10.1038/modpathol.2009.151 | PMID = 19855376 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2886398/figure/F2/ Collagenous sprue (nih.gov)].<ref name=pmid20574500>{{Cite journal | last1 = Xiao | first1 = Z. | last2 = Dasari | first2 = VM. | last3 = Kirby | first3 = DF. | last4 = Bronner | first4 = M. | last5 = Plesec | first5 = TP. | last6 = Lashner | first6 = BA. | title = Collagenous sprue: a case report and literature review. | journal = Gastroenterol Hepatol (N Y) | volume = 5 | issue = 6 | pages = 418-24 | month = Jun | year = 2009 | doi = | PMID = 20574500 }}</ref> | |||
==Stains== | |||
Stains to demonstrate collagen: | |||
*[[Mallory trichrome stain|Mallory trichrome]]. | |||
*[[Masson trichrome stain|Masson trichrome]]. | |||
==See also== | ==See also== | ||