Difference between revisions of "Chronic traumatic encephalopathy"
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'''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases|neurodegenerative disease]] due to repeated trauma. | '''Chronic traumatic encephalopathy''', abbreviated '''CTE''', is a [[Neurodegenerative diseases|neurodegenerative disease]] due to repeated trauma. | ||
The in the context of boxing it is known as '''dementia pugilistica'''; ''pugil'' is ''boxer'' in Latin.<ref>URL: [http://dictionary.reference.com/browse/pugilism http://dictionary.reference.com/browse/pugilism]. Accessed on: 21 November 2011.</ref> | |||
==General== | ==General== | ||
*Due to head trauma - usually repetitive. | *Due to head trauma - usually repetitive. | ||
**Seen in ''American football'' and ''boxing''. | **Seen in ''American football'' and ''boxing''. | ||
*May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal | last1 = Daneshvar | first1 = DH. | last2 = Riley | first2 = DO. | last3 = Nowinski | first3 = CJ. | last4 = McKee | first4 = AC. | last5 = Stern | first5 = RA. | last6 = Cantu | first6 = RC. | title = Long-term consequences: effects on normal development profile after concussion. | journal = Phys Med Rehabil Clin N Am | volume = 22 | issue = 4 | pages = 683-700 | month = Nov | year = 2011 | doi = 10.1016/j.pmr.2011.08.009 | PMID = 22050943 }}</ref> | *May be associated with motor neuron disease.<ref name=pmid22050943>{{Cite journal | last1 = Daneshvar | first1 = DH. | last2 = Riley | first2 = DO. | last3 = Nowinski | first3 = CJ. | last4 = McKee | first4 = AC. | last5 = Stern | first5 = RA. | last6 = Cantu | first6 = RC. | title = Long-term consequences: effects on normal development profile after concussion. | journal = Phys Med Rehabil Clin N Am | volume = 22 | issue = 4 | pages = 683-700 | month = Nov | year = 2011 | doi = 10.1016/j.pmr.2011.08.009 | PMID = 22050943 }}</ref> | ||
Revision as of 21:50, 16 February 2015
Chronic traumatic encephalopathy, abbreviated CTE, is a neurodegenerative disease due to repeated trauma.
The in the context of boxing it is known as dementia pugilistica; pugil is boxer in Latin.[1]
General
- Due to head trauma - usually repetitive.
- Seen in American football and boxing.
- May be associated with motor neuron disease.[2]
Microscopic
Features:[3]
- Wall-to-wall neurofibrillary tangles.
- Common in olfactory bulb, mammillary bodies, hippocampus.
- Usually perivascular.
- Often superficial (unlike Alzheimer disease) and at the deep aspect of sulci.
IHC
- Increased TDP-43 staining.
Note:
See also
References
- ↑ URL: http://dictionary.reference.com/browse/pugilism. Accessed on: 21 November 2011.
- ↑ Daneshvar, DH.; Riley, DO.; Nowinski, CJ.; McKee, AC.; Stern, RA.; Cantu, RC. (Nov 2011). "Long-term consequences: effects on normal development profile after concussion.". Phys Med Rehabil Clin N Am 22 (4): 683-700. doi:10.1016/j.pmr.2011.08.009. PMID 22050943.
- ↑ Stern, RA.; Riley, DO.; Daneshvar, DH.; Nowinski, CJ.; Cantu, RC.; McKee, AC. (Oct 2011). "Long-term Consequences of Repetitive Brain Trauma: Chronic Traumatic Encephalopathy.". PM R 3 (10 Suppl 2): S460-7. doi:10.1016/j.pmrj.2011.08.008. PMID 22035690.
- ↑ Costanza, A.; Weber, K.; Gandy, S.; Bouras, C.; Hof, PR.; Giannakopoulos, P.; Canuto, A. (Oct 2011). "Review: Contact sport-related chronic traumatic encephalopathy in the elderly: clinical expression and structural substrates.". Neuropathol Appl Neurobiol 37 (6): 570-84. doi:10.1111/j.1365-2990.2011.01186.x. PMID 21696410.