Difference between revisions of "Chordoma"

From Libre Pathology
Jump to navigation Jump to search
(split-out)
Line 30: Line 30:
<gallery>
<gallery>
Image:Chordoma_-_low_mag.jpg | Chordoma - low mag. (WC)
Image:Chordoma_-_low_mag.jpg | Chordoma - low mag. (WC)
Image:Chordoma - intermed mag.jpg| Chordoma - intermed. mag. (WC)
Image:Chordoma_-_high_mag.jpg | Chordoma - high mag. (WC)
Image:Chordoma_-_high_mag.jpg | Chordoma - high mag. (WC)
Image:Chordoma - very high mag.jpg| Chordoma - very high mag. (WC)
</gallery>
</gallery>
www:
www:

Revision as of 15:45, 1 October 2013

Chordoma is an uncommon tumour in neuropathology.

General

  • Location: usually sacrum or clivus.
  • It is a bone tumour.

Gross

  • Soft, gelatinous, lobulated.[1]

DDx:

  • Bony metastasis (mucinous carcinoma) - typically multifocal.

Image:

Microscopic

Features:[2]

  • Architecture: islands of cells surrounded by fibrous tissue.
    • Also described as "lobulated" architecture; may not be apparent.
  • Myxoid background - grey extracellular material, variable amount present.
  • Mixed cell population:
    1. Abundant eosinophilic cytoplasm.
    2. Physaliphorous cells or bubble cells - key feature.
      • Have a very large clear bubble with a sharp border; bubble does not compress nucleus - nucleus may be in bubble.

DDx:

Images

www:

IHC

Features:[3][4]

  • S100 +ve.
  • AE1/AE3 +ve.
  • Brachyury +ve -- key stain.
    • Protein important for axial development, affects notochord development.[5]
    • Brachyury literally means short tail.[6]
  • EMA +ve.

See also

References

  1. URL: http://www.histopathology-india.net/Chordoma.htm. Accessed on: 12 April 2012.
  2. Tadrous, Paul.J. Diagnostic Criteria Handbook in Histopathology: A Surgical Pathology Vade Mecum (1st ed.). Wiley. pp. 184. ISBN 978-0470519035.
  3. URL: http://path.upmc.edu/cases/case312/micro.html. Accessed on: 14 January 2012.
  4. Coindre, JM.; Rivel, J.; Trojani, M.; De Mascarel, I.; De Mascarel, A. (Sep 1986). "Immunohistological study in chordomas.". J Pathol 150 (1): 61-3. doi:10.1002/path.1711500110. PMID 2431128.
  5. Online 'Mendelian Inheritance in Man' (OMIM) 601397
  6. URL: http://www.jstor.org/pss/86845. Accessed on: 18 May 2010.