Difference between revisions of "Chondrosarcoma"

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Chondrosarcoma (view source)

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====[[Mesenchymal chondrosarcoma]]====
====[[Mesenchymal chondrosarcoma]]====
*Arise in soft tissue; this is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref>
*Arise in soft tissue; this is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref>
==General==
*Rare variant of chondrosarcoma.
*Rare variant of chondrosarcoma.
*2–10% of primary chondrosarcomas
*Adolescents and young adults
*Female predilection
*Most commonly intraosseous but can occur in extraskeletal sites especially the central nervous system (from the meminges)
*Conceptualized as originating from a pleuripotential mesenchymal cell with foci recapitulating enchondral ossification.
*The small cells appear to be an undifferentiated cartilage stem cell which “differentiate” into benign cartilage <ref>{{Cite journal  | last1 = Fanburg-Smith | first1 = JC. | last2 = Auerbach | first2 = A. | last3 = Marwaha | first3 = JS. | last4 = Wang | first4 = Z. | last5 = Rushing | first5 = EJ. | title = Reappraisal of mesenchymal chondrosarcoma: novel morphologic observations of the hyaline cartilage and endochondral ossification and beta-catenin, Sox9, and osteocalcin immunostaining of 22 cases. | journal = Hum Pathol | volume = 41 | issue = 5 | pages = 653-62 | month = May | year = 2010 | doi = 10.1016/j.humpath.2009.11.006 | PMID = 20138330 }}
</ref>.
This is where the name comes from.<ref name=pmid14161087>{{cite journal |author=Dowling EA |title=Mesenchymal chondrosarcoma |journal=J Bone Joint Surg Am |volume=46 |issue= |pages=747–54 |year=1964 |month=June |pmid=14161087 |doi= |url=http://www.ejbjs.org/cgi/reprint/46/4/747.pdf}}</ref>


==Gross==
Microscopic:
Pink and fleshy with foci of calcification.
Features:
 
==Microscopic==
*"White clouds in a blue sky".
*"White clouds in a blue sky".
*Malignant tumor with a characteristic biphasic pattern
**Cellular poorly differentiated small round blue cells
**Islands of well-differentiated hyaline cartilage
***Progressive maturation of cartilage towards the center
***Central calcification or bone formation
==IHC==
*SOX9 (positive in small cells and chondrocytes)
*S100 (positive in chondrocytes)
*Osteocalcin (negative in small cells)
==Molecular==
t(8;8)(q21.1;q13.3) HEY1-NCOA2


==Photos==
<gallery>
*[[File:Bone Chondrosarcoma Mesenchymal MP5 PA.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal MP PA.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal LP2 PA.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal HP5 PA.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal MP2 PA.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal MP7.JPG|Islands of cartilage in a background of small blue cells.]]
*[[File:Bone Chondrosarcoma Mesenchymal HP3 PA.JPG|Small blue cells predominate]]
</gallery>
==See also==
Image:
Image:
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].
*[http://moon.ouhsc.edu/kfung/jty1/opaq/PathQuiz/S0A001-PQ01-M.htm Mesenchymal chondrosarcoma (ouhsc.edu)].
==References==
{{Reflist|1}}


====Myxoid chondrosarcoma====
====Myxoid chondrosarcoma====
Sarah
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